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- W95472144 abstract "Pancreatic adenocarcinoma (PC) is the third most common noncutaneous malignancy and the second most common gastrointestinal malignancy in the United States.1 Up to 90% of all PCs are ductal in origin.2 PC carries a dismal prognosis, with 5-year survival rates after potentially curative resection of only 10—25%.1,3,4 The overall 5-year survival rate for PC is less than 5%, since only 15—20% of patients are deemed to be operative candidates on presentation.5 Primary pancreatic lymphoma (PPL) is an exceedingly rare type of extra-nodal non-Hodgkin lymphoma (NHL) that comprises less than 0.5% of all pancreatic tumors.6 PPL must be differentiated from NHL with secondary pancreatic involvement from retroperitoneal and/or pariaortic lymphadenopathy, which can occur in 30—40% of NHL cases with extranodal disease. Compared to PC, PPL may not require operative intervention, carries a much better overall prognosis, and responds to combined chemotherapy and radiotherapy. In addition, new targeted immunotherapeutic agents can improve survival, and targeted radioimmunotherapy may be effective in refractory disease. As Alexander and coauthors illustrate, differentiating PPL from PC can be challenging because of the significant overlap in presenting symptoms.7 However, differentiation of PPL from PC is of critical importance for appropriate therapeutic planning. Correct preoperative diagnosis of PPL in the case by Alexander and coauthors could have allowed the patient to avoid the morbidity of pancreatic surgery (and perhaps the morbidity of an endoscopic biliary stent) and could have allowed for earlier initiation of targeted therapy for this potentially curable disease." @default.
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- W95472144 date "2011-12-01" @default.
- W95472144 modified "2023-09-23" @default.
- W95472144 title "Pancreatic tumor: when is it not pancreatic adenocarcinoma?" @default.
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