FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W9547429> ?p ?o ?g. }

• W9547429 abstract "Introduction: This is a prospective study of kif6, a genetic biomarker of cardiovascular disease and efficacy for statin therapy, using retrospective analysis of cardiac history. We explored the association between kif6 and cardiovascular disease (CVD) events (ACS, atherosclerosis with PCI or CABG) as well as the frequency of kif6 in Asians. In previous studies, carriers of kif6 had a higher incidence of CVD than non-carriers. The identification of a patient’s kif6 status may have impact on the therapeutic approach to reduce CVD risk. Hypothesis: Kif6 carriers with no or low dosage of statins have a higher rate of cardiovascular disease and treatment with higher dose statins have significant reduction in their rate of CVD events. Methods: We enrolled 135 patients from UCSF to determine kif6 carrier status and a review of their cardiac history. We analyzed the associations between high (40mg) vs. low (< 20 mg) in carriers and non-carriers and accounted for CVD events. For 11 patients, the statin dose at the time of their CVD event was unknown. Given the standard of care practice, this group was assigned to low statin. Result: Prevalence of kif6 mutation in Asians is 72%. Kif6-carriers with low/no statin have higher rates of CVD events (38%) compared to those on high dose statin (13%). Kif6-non carriers did not have significant reduction in CVD events with statin treatment. Study selection bias was a referral population from the community for secondary cardiovascular care at UCSF and small study size. However, enrollment is continuing. Other possible biases are presence of co-morbidities, e.g., smoking status, lifestyle habitus, Diabetes, and hypertension. Conclusion: This is the first prospective study looking at kif6 mutation prevalence and impact in Asians. The prevalence of kif6 mutation is high among Asians. Kif6-carrier is predictive of CVD events. There is definitive benefit of high-dose statin therapy for kif6-carriers with reduction in CVD events. There is no definitive benefit of statin therapy for non-carriers. Table Kif6-Carrier: (n= 97) Kif6-Non-carrier: (n=37) Low statin, no CVD event 46 15 Low statin, w/ CVD event 28 10 Total 74 25 Event rate 38% 40% High statin, no CVD event 20 9 High statin, w/ CVD event 3 3 Total 23 12 Event rate 13% 25% P-value 0.0468 0.5983" @default.
• W9547429 created "2016-06-24" @default.
• W9547429 creator A5026508093 @default.
• W9547429 creator A5027141376 @default.
• W9547429 creator A5027170915 @default.
• W9547429 creator A5060351841 @default.
• W9547429 creator A5079517489 @default.
• W9547429 date "2012-03-13" @default.
• W9547429 modified "2023-09-23" @default.
• W9547429 title "Abstract P327: KIF6 Carrier Status in Asians Predicts Beneficial Response to Statins" @default.
• W9547429 doi "https://doi.org/10.1161/circ.125.suppl_10.ap327" @default.
• W9547429 hasPublicationYear "2012" @default.
• W9547429 type Work @default.
• W9547429 sameAs 9547429 @default.
• W9547429 citedByCount "1" @default.
• W9547429 countsByYear W95474292013 @default.
• W9547429 crossrefType "journal-article" @default.
• W9547429 hasAuthorship W9547429A5026508093 @default.
• W9547429 hasAuthorship W9547429A5027141376 @default.
• W9547429 hasAuthorship W9547429A5027170915 @default.
• W9547429 hasAuthorship W9547429A5060351841 @default.
• W9547429 hasAuthorship W9547429A5079517489 @default.
• W9547429 hasConcept C126322002 @default.
• W9547429 hasConcept C164705383 @default.
• W9547429 hasConcept C2776839432 @default.
• W9547429 hasConcept C2779134260 @default.
• W9547429 hasConcept C2908647359 @default.
• W9547429 hasConcept C500558357 @default.
• W9547429 hasConcept C71924100 @default.
• W9547429 hasConcept C99454951 @default.
• W9547429 hasConceptScore W9547429C126322002 @default.
• W9547429 hasConceptScore W9547429C164705383 @default.
• W9547429 hasConceptScore W9547429C2776839432 @default.
• W9547429 hasConceptScore W9547429C2779134260 @default.
• W9547429 hasConceptScore W9547429C2908647359 @default.
• W9547429 hasConceptScore W9547429C500558357 @default.
• W9547429 hasConceptScore W9547429C71924100 @default.
• W9547429 hasConceptScore W9547429C99454951 @default.
• W9547429 hasIssue "suppl_10" @default.
• W9547429 hasLocation W95474291 @default.
• W9547429 hasOpenAccess W9547429 @default.
• W9547429 hasPrimaryLocation W95474291 @default.
• W9547429 hasRelatedWork W2018585805 @default.
• W9547429 hasRelatedWork W2119852139 @default.
• W9547429 hasRelatedWork W2165119695 @default.
• W9547429 hasRelatedWork W2316107365 @default.
• W9547429 hasRelatedWork W2367140913 @default.
• W9547429 hasRelatedWork W2377483921 @default.
• W9547429 hasRelatedWork W2384102316 @default.
• W9547429 hasRelatedWork W2411183214 @default.
• W9547429 hasRelatedWork W2443697580 @default.
• W9547429 hasRelatedWork W2595649087 @default.
• W9547429 hasVolume "125" @default.
• W9547429 isParatext "false" @default.
• W9547429 isRetracted "false" @default.
• W9547429 magId "9547429" @default.
• W9547429 workType "article" @default.