Matches in SemOpenAlex for { <https://semopenalex.org/work/W9548462> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W9548462 endingPage "56" @default.
- W9548462 startingPage "247" @default.
- W9548462 abstract "Therapeutic oligonucleotides - short strands of synthetic nucleic acids - encompass antisense and aptamer oligonucleotides. Antisense oligonucleotides are designed to bind to target RNA by complementary base pairing and to inhibit translation of the target protein. Antisense oligonucleotides enable specific inhibition of cytokine synthesis. In contrast, aptamer oligonucleotides are able to bind directly to specific proteins. This binding depends on the sequence of the oligonucleotide. Aptamer oligonucleotides with CpG motifs can exert strong immunostimulatory effects. Both kinds of therapeutic oligonucleotides - antisense and aptamer oligonucleotides - provide promising tools to modulate immunological functions. Recently, therapeutic oligonucleotides have moved towards clinical application. An antisense oligonucleotide directed against the proinflammatory intercellular adhesion molecule 1 (ICAM-1) is currently being tested in clinical trials for therapy of inflammatory disease. Immunostimulatory aptamer oligonucleotides are in preclinical development for immunotherapy. In the present review we summarize the application of therapeutic oligonucleotides to modulate immunological functions. We include technological aspects as well as current therapeutic concepts and clinical studies." @default.
- W9548462 created "2016-06-24" @default.
- W9548462 creator A5036493478 @default.
- W9548462 creator A5047105687 @default.
- W9548462 creator A5057394610 @default.
- W9548462 creator A5070273513 @default.
- W9548462 creator A5073459990 @default.
- W9548462 date "1997-12-01" @default.
- W9548462 modified "2023-09-27" @default.
- W9548462 title "Cytokines and therapeutic oligonucleotides." @default.
- W9548462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9740353" @default.
- W9548462 hasPublicationYear "1997" @default.
- W9548462 type Work @default.
- W9548462 sameAs 9548462 @default.
- W9548462 citedByCount "6" @default.
- W9548462 crossrefType "journal-article" @default.
- W9548462 hasAuthorship W9548462A5036493478 @default.
- W9548462 hasAuthorship W9548462A5047105687 @default.
- W9548462 hasAuthorship W9548462A5057394610 @default.
- W9548462 hasAuthorship W9548462A5070273513 @default.
- W9548462 hasAuthorship W9548462A5073459990 @default.
- W9548462 hasConcept C104317684 @default.
- W9548462 hasConcept C122682173 @default.
- W9548462 hasConcept C128972844 @default.
- W9548462 hasConcept C129312508 @default.
- W9548462 hasConcept C153911025 @default.
- W9548462 hasConcept C24107716 @default.
- W9548462 hasConcept C552990157 @default.
- W9548462 hasConcept C55493867 @default.
- W9548462 hasConcept C67705224 @default.
- W9548462 hasConcept C86803240 @default.
- W9548462 hasConceptScore W9548462C104317684 @default.
- W9548462 hasConceptScore W9548462C122682173 @default.
- W9548462 hasConceptScore W9548462C128972844 @default.
- W9548462 hasConceptScore W9548462C129312508 @default.
- W9548462 hasConceptScore W9548462C153911025 @default.
- W9548462 hasConceptScore W9548462C24107716 @default.
- W9548462 hasConceptScore W9548462C552990157 @default.
- W9548462 hasConceptScore W9548462C55493867 @default.
- W9548462 hasConceptScore W9548462C67705224 @default.
- W9548462 hasConceptScore W9548462C86803240 @default.
- W9548462 hasIssue "4" @default.
- W9548462 hasLocation W95484621 @default.
- W9548462 hasOpenAccess W9548462 @default.
- W9548462 hasPrimaryLocation W95484621 @default.
- W9548462 hasRelatedWork W127848729 @default.
- W9548462 hasRelatedWork W1556484532 @default.
- W9548462 hasRelatedWork W2017345968 @default.
- W9548462 hasRelatedWork W2114783261 @default.
- W9548462 hasRelatedWork W2133282256 @default.
- W9548462 hasRelatedWork W2287289200 @default.
- W9548462 hasRelatedWork W2411683166 @default.
- W9548462 hasRelatedWork W2594952820 @default.
- W9548462 hasRelatedWork W2980933109 @default.
- W9548462 hasRelatedWork W3209157902 @default.
- W9548462 hasVolume "3" @default.
- W9548462 isParatext "false" @default.
- W9548462 isRetracted "false" @default.
- W9548462 magId "9548462" @default.
- W9548462 workType "article" @default.