Matches in SemOpenAlex for { <https://semopenalex.org/work/W955129780> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W955129780 endingPage "13" @default.
- W955129780 startingPage "10" @default.
- W955129780 abstract "目的通过观察神经管畸形（Neural Tube Defects，NTDs）患儿与正常胎儿脑组织中DNA错配修复（mismatch repair，MMR）蛋白MLH1、PMS2、MSH2及MSH6的表达情况，探讨MMR系统与NTDs发生机理间可能存在的联系。方法NTDs患儿脑组织及正常胎儿脑组织各15例，运用免疫组化方法检测各病例中MLH1、PMs2、MSH2及MSH6蛋白表达情况。结果NTDs组MLH1阳性率中位数为1．44％，正常组为（41．96±11．01）％，中位数为43．95％；NTDs组PMS2阳性率为（25．48±16．46）％；正常组为（43．36±7．86）％。NTDs组中两种蛋白较正常组明显下降，组间存在统计学差异（P〈0．01）。但NTDs组中MSH2及MsH6阳性率分别为（43．56±18．67）％、（32．26±23．18）％；正常组中为（45．87±8．49）％、（35．15±10．68）％。两种蛋白组间比较无统计学差异，P值分别为0．6516和0．5387。结论首次报道NTDs中可能存在一种或多种特定MMR蛋白表达异常，推测MMR系统表达异常可能在NTDs发生过程中起到重要作用。" @default.
- W955129780 created "2016-06-24" @default.
- W955129780 creator A5011810381 @default.
- W955129780 creator A5012739551 @default.
- W955129780 creator A5014300315 @default.
- W955129780 creator A5019661448 @default.
- W955129780 creator A5055469893 @default.
- W955129780 creator A5065942665 @default.
- W955129780 date "2010-01-01" @default.
- W955129780 modified "2023-10-18" @default.
- W955129780 title "DNA错配修复蛋白(MLH1,PMS2,MSH2,MSH6)与人类神经管畸形(NTDs)关联性的初步研究" @default.
- W955129780 hasPublicationYear "2010" @default.
- W955129780 type Work @default.
- W955129780 sameAs 955129780 @default.
- W955129780 citedByCount "0" @default.
- W955129780 crossrefType "journal-article" @default.
- W955129780 hasAuthorship W955129780A5011810381 @default.
- W955129780 hasAuthorship W955129780A5012739551 @default.
- W955129780 hasAuthorship W955129780A5014300315 @default.
- W955129780 hasAuthorship W955129780A5019661448 @default.
- W955129780 hasAuthorship W955129780A5055469893 @default.
- W955129780 hasAuthorship W955129780A5065942665 @default.
- W955129780 hasConcept C111425858 @default.
- W955129780 hasConcept C134935766 @default.
- W955129780 hasConcept C2776674815 @default.
- W955129780 hasConcept C2778677574 @default.
- W955129780 hasConcept C2779115348 @default.
- W955129780 hasConcept C54355233 @default.
- W955129780 hasConcept C552990157 @default.
- W955129780 hasConcept C60748783 @default.
- W955129780 hasConcept C86803240 @default.
- W955129780 hasConceptScore W955129780C111425858 @default.
- W955129780 hasConceptScore W955129780C134935766 @default.
- W955129780 hasConceptScore W955129780C2776674815 @default.
- W955129780 hasConceptScore W955129780C2778677574 @default.
- W955129780 hasConceptScore W955129780C2779115348 @default.
- W955129780 hasConceptScore W955129780C54355233 @default.
- W955129780 hasConceptScore W955129780C552990157 @default.
- W955129780 hasConceptScore W955129780C60748783 @default.
- W955129780 hasConceptScore W955129780C86803240 @default.
- W955129780 hasIssue "5" @default.
- W955129780 hasLocation W9551297801 @default.
- W955129780 hasOpenAccess W955129780 @default.
- W955129780 hasPrimaryLocation W9551297801 @default.
- W955129780 isParatext "false" @default.
- W955129780 isRetracted "false" @default.
- W955129780 magId "955129780" @default.
- W955129780 workType "article" @default.