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- W95523629 abstract "In addition to its well-known excretory function, the mammalian kidney has important metabolic and endocrine functions such as gluconeogenesis, production of the active compound of the vitamin D system, erythropoietin synthesis and release, and secretion of renin, which ultimately leads to generation of the vasoconstrictor angiotensin II and release of the mineralocorticoid aldosterone. The renin-angiotensin-aldosterone axis, the so-called prohypertensive renal function, together with the sympathetic nervous system, represent at least two of the major known mechanisms for production of an elevated blood pressure. Evidence that activation of prohypertensive renal principles might underlie the etiology of human hypertension received great impetus from the studies of Goldblatt in 1934 [1] which showed that partial renal artery occlusion raised arterial blood pressure — a finding subsequently associated with an increase in the activity of the renin-angiotensin axis." @default.
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- W95523629 date "1982-01-01" @default.
- W95523629 modified "2023-09-28" @default.
- W95523629 title "Role of the Renin-Angiotensin System and Prostaglandins in Blood Pressure Regulation and Sodium Homeostasis" @default.
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- W95523629 doi "https://doi.org/10.1007/978-94-009-7476-0_5" @default.
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