Matches in SemOpenAlex for { <https://semopenalex.org/work/W955247251> ?p ?o ?g. }
- W955247251 endingPage "4880" @default.
- W955247251 startingPage "4866" @default.
- W955247251 abstract "In Caenorhabditis elegans, homodimeric [kinesin family (KIF) 17, osmotic avoidance abnormal-3 (OSM-3)] and heterotrimeric (KIF3) kinesin-2 motors are required to establish sensory cilia by intraflagellar transport (IFT) where KIF3 and KIF17 cooperate to build the axoneme core and KIF17 builds the distal segments. However, the function of KIF17 in vertebrates is unresolved. We expressed full-length and motorless KIF17 constructs in mouse rod photoreceptors using adeno-associated virus in Xenopus laevis rod photoreceptors using a transgene and in ciliated IMCD3 cells. We found that tagged KIF17 localized along the rod outer segment axoneme when expressed in mouse and X. laevis photoreceptors, whereas KIF3A was restricted to the proximal axoneme. Motorless KIF3A and KIF17 mutants caused photoreceptor degeneration, likely through dominant negative effects on IFT. KIF17 mutant lacking the motor domain translocated to nuclei after exposure of a C-terminal nuclear localization signal. Germ-line deletion of Kif17 in mouse did not affect photoreceptor function. A rod-specific Kif3/Kif17 double knockout mouse demonstrated that KIF17 and KIF3 do not act synergistically and did not prevent rhodopsin trafficking to rod outer segments. In summary, the nematode model of KIF3/KIF17 cooperation apparently does not apply to mouse photoreceptors in which the photosensory cilium is built exclusively by KIF3." @default.
- W955247251 created "2016-06-24" @default.
- W955247251 creator A5002527697 @default.
- W955247251 creator A5005951752 @default.
- W955247251 creator A5017561547 @default.
- W955247251 creator A5021532550 @default.
- W955247251 creator A5059469814 @default.
- W955247251 creator A5066740891 @default.
- W955247251 creator A5069486760 @default.
- W955247251 creator A5076578673 @default.
- W955247251 date "2015-07-30" @default.
- W955247251 modified "2023-10-18" @default.
- W955247251 title "Kinesin family 17 (osmotic avoidance abnormal‐3) is dispensable for photoreceptor morphology and function" @default.
- W955247251 cites W193528990 @default.
- W955247251 cites W1967429245 @default.
- W955247251 cites W1968127700 @default.
- W955247251 cites W1977604108 @default.
- W955247251 cites W1985468162 @default.
- W955247251 cites W1990152917 @default.
- W955247251 cites W1996637041 @default.
- W955247251 cites W1996743997 @default.
- W955247251 cites W2005619876 @default.
- W955247251 cites W2005816854 @default.
- W955247251 cites W2005843619 @default.
- W955247251 cites W2007114792 @default.
- W955247251 cites W2009432227 @default.
- W955247251 cites W2023843317 @default.
- W955247251 cites W2025722885 @default.
- W955247251 cites W2033052818 @default.
- W955247251 cites W2037709331 @default.
- W955247251 cites W2043090020 @default.
- W955247251 cites W2043725913 @default.
- W955247251 cites W2046966521 @default.
- W955247251 cites W2051159468 @default.
- W955247251 cites W2053132003 @default.
- W955247251 cites W2061604906 @default.
- W955247251 cites W2068918824 @default.
- W955247251 cites W2073745454 @default.
- W955247251 cites W2076781545 @default.
- W955247251 cites W2078477084 @default.
- W955247251 cites W2081291985 @default.
- W955247251 cites W208257085 @default.
- W955247251 cites W2086790354 @default.
- W955247251 cites W2091321172 @default.
- W955247251 cites W2091790812 @default.
- W955247251 cites W2095254823 @default.
- W955247251 cites W2096335714 @default.
- W955247251 cites W2115388245 @default.
- W955247251 cites W2129126752 @default.
- W955247251 cites W2157217942 @default.
- W955247251 cites W2159740254 @default.
- W955247251 cites W2161369215 @default.
- W955247251 cites W2168029064 @default.
- W955247251 cites W2168230734 @default.
- W955247251 cites W2170986006 @default.
- W955247251 cites W2188737084 @default.
- W955247251 cites W2333599119 @default.
- W955247251 cites W33968448 @default.
- W955247251 cites W46162329 @default.
- W955247251 doi "https://doi.org/10.1096/fj.15-275677" @default.
- W955247251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4653055" @default.
- W955247251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26229057" @default.
- W955247251 hasPublicationYear "2015" @default.
- W955247251 type Work @default.
- W955247251 sameAs 955247251 @default.
- W955247251 citedByCount "38" @default.
- W955247251 countsByYear W9552472512015 @default.
- W955247251 countsByYear W9552472512016 @default.
- W955247251 countsByYear W9552472512017 @default.
- W955247251 countsByYear W9552472512018 @default.
- W955247251 countsByYear W9552472512019 @default.
- W955247251 countsByYear W9552472512020 @default.
- W955247251 countsByYear W9552472512021 @default.
- W955247251 countsByYear W9552472512022 @default.
- W955247251 countsByYear W9552472512023 @default.
- W955247251 crossrefType "journal-article" @default.
- W955247251 hasAuthorship W955247251A5002527697 @default.
- W955247251 hasAuthorship W955247251A5005951752 @default.
- W955247251 hasAuthorship W955247251A5017561547 @default.
- W955247251 hasAuthorship W955247251A5021532550 @default.
- W955247251 hasAuthorship W955247251A5059469814 @default.
- W955247251 hasAuthorship W955247251A5066740891 @default.
- W955247251 hasAuthorship W955247251A5069486760 @default.
- W955247251 hasAuthorship W955247251A5076578673 @default.
- W955247251 hasBestOaLocation W9552472512 @default.
- W955247251 hasConcept C100094513 @default.
- W955247251 hasConcept C104317684 @default.
- W955247251 hasConcept C115811362 @default.
- W955247251 hasConcept C143065580 @default.
- W955247251 hasConcept C20418707 @default.
- W955247251 hasConcept C24870808 @default.
- W955247251 hasConcept C2778944004 @default.
- W955247251 hasConcept C37590093 @default.
- W955247251 hasConcept C54355233 @default.
- W955247251 hasConcept C59006786 @default.
- W955247251 hasConcept C86803240 @default.
- W955247251 hasConcept C95444343 @default.
- W955247251 hasConceptScore W955247251C100094513 @default.