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- W95525892 abstract "We are living through an exciting era for cancer drug discovery and development—one that is full of enormous opportunities and challenges. In this chapter, we aim to capture the sense of excitement and to describe the opportunities and challenges in the discovery and design of molecularly targeted small-molecule cancer drugs. In particular, we stress the importance of integrating three key themes: targets, technologies, and treatments. First, the molecular targets of contemporary drug discovery projects reflect our increased understanding of the genetic or epigenetic dysregulation of cellular processes that leads to the initiation and malignant progression of cancer. We describe different ways in which potential new molecular targets can be identified, validated, and prioritized. Second, we highlight the integrated application of a range of powerful drug discovery technologies, including genomic methods, compound screening methodologies, and the application of structural biology. We describe the multidisciplinary endeavor of small-molecule cancer drug discovery and emphasize how the challenges of multiparameter lead optimization are being met. Third, we examine how technological innovations in drug design have led to the new treatments that have emerged over the past 15 years. We show how the development and use of such treatments depend on the identification of biomarkers to select appropriate patients and to monitor the effects of treatment. Finally, we reflect on the success to date of mechanism-based molecular therapeutics acting on cancer-causing targets and outline the future prospects for the enhanced development of personalized molecular medicines, highlighting the need for combinatorial drug treatments to overcome the enduring problem of drug resistance." @default.
- W95525892 created "2016-06-24" @default.
- W95525892 creator A5003965204 @default.
- W95525892 creator A5007384881 @default.
- W95525892 date "2014-01-01" @default.
- W95525892 modified "2023-09-27" @default.
- W95525892 title "Modern Cancer Drug Discovery" @default.
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