Matches in SemOpenAlex for { <https://semopenalex.org/work/W955336216> ?p ?o ?g. }
- W955336216 abstract "The cholinergic basal forebrain is composed of a collection of magnocellular hyperchromic neurons located within the septal/diagonal band complex and nucleus basalis of Meynert. These neurons provide the major cholinergic innervation to the hippocampus and neocortical mantle. Empirical investigations since the 1980s have established a role for the cholinergic basal forebrain in higher order cognitive processes, although its exact role in attentional versus memory processes remains an area of debate. The fact that the cholinergic basal forebrain degenerates in dementing illnesses such as Alzheimer's disease (AD) underscores the importance for understanding the structural and functional aspects of this region. Further, the cholinergic basal forebrain system is intimately linked with trophic factor systems as these neurons contain the appropriate receptors for, and are exquisitely sensitive to, neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor. This chapter focuses on the neuroanatomical and neurochemical organization of the primate cholinergic basal forebrain, with special reference where appropriate to the organizational properties of the human brain and its relation to aging and dementia. The importance of understanding human cholinergic basal forebrain function is featured as this region displays a unique species-specific organization, especially as it pertains to its relationships with peptidergic systems and the expression of the estrogen receptor within the primate cholinergic basal forebrain as compared to nonprimates. Whether these species differences underlie the vulnerability of cholinergic basal forebrain neurons in diseases of higher order cognitive function remains a mystery. Finally, experimental therapeutic strategies aimed at augmenting the survival of cholinergic basal forebrain neurons, including NGF administration or fetal cholinergic grafting, are discussed." @default.
- W955336216 created "2016-06-24" @default.
- W955336216 creator A5072527270 @default.
- W955336216 creator A5074765508 @default.
- W955336216 date "2001-01-01" @default.
- W955336216 modified "2023-09-27" @default.
- W955336216 title "Cholinergic Basal Forebrain Systems in the Primate Central Nervous System: Anatomy, Connectivity, Neurochemistry, Aging, Dementia, and Experimental Therapeutics" @default.
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