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- W955694533 abstract "There is a growing consensus that long-term deficits in the brain are due to dynamic interactions between multiple neural and immune cell types. Specifically, radiation induces an inflammatory response, including changes in neuromodulatory pro- and anti-inflammatory cytokine secretion. The purpose of this study was to establish that there is sympathetic involvement in radiation-induced decrements early in in vivo immune function host defense. Female, 8-9 week-old C57BL/6J mice were exposed to whole-body irradiation (WBI). There were 8 groups with radiation (0 vs. 3 Gy protons), immune challenge (Escherichia coli) and exposure to the sympathetic ganglionic blocker, chlorisondamine (1 mg/kg weight, i.p.), as independent variables. Ten days post-irradiation, mice were inoculated with E. coli intraperitoneally and sacrificed 90-120 min later. The data suggest that radiation-induced changes in immune function may in part be mediated by the sympathetic nervous system. Briefly, we found that radiation augments the bacteria-induced inflammatory cytokine response, particularly those cytokines involved in innate immunity. However, this augmentation can be reduced by the ganglionic blockade." @default.
- W955694533 created "2016-06-24" @default.
- W955694533 creator A5003856552 @default.
- W955694533 creator A5009118049 @default.
- W955694533 creator A5028857100 @default.
- W955694533 creator A5028877127 @default.
- W955694533 creator A5058828141 @default.
- W955694533 creator A5060817429 @default.
- W955694533 date "2015-10-01" @default.
- W955694533 modified "2023-09-26" @default.
- W955694533 title "Chlorisondamine, a sympathetic ganglionic blocker, moderates the effects of whole-body irradiation (WBI) on early host defense to a live bacterial challenge" @default.
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- W955694533 doi "https://doi.org/10.1016/j.imlet.2015.07.008" @default.