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- W95574488 abstract "OBJECTIVE: To analyse the efficacy of Auto-PBSCT on disability and ENMG patterns in patients with POEMS syndrome. BACKGROUND: POEMS syndrome (Polyneuropathy, organomegaly, endocrynopathy, M-protein, and skin changes) is a rare multisystem disease associated with a plasma cell dyscrasia. Efficacy of Auto-PBSCT have been reported in case series on haematologic criteria only, clinical recovery of peripheral neuropathy dysfunctions was not specifically evaluated. DESIGN/METHODS: Five patients presenting with POEMS syndrome received Auto-PBSCT. Disability was evaluated before treatment and at 6 and 12 months through Overall Neuropathy Limitation Scale (ONLS) and MRC sumscore of 28 muscles. Nerve conduction studies were performed before and one year after treatment, on median, ulnar, peroneal and tibial nerves. Mann–Whitney test was used for statistical analysis. RESULTS: Mean age was 60.6 years (49-70yr). Disease duration between first symptoms and auto-PBSCT was 15.4 months (2-33). Before Auto-PBSCT, mean ONLS score was 4.2 (1-10) and MRC sumscore 115.8/140 (74-140). At M6, mean ONLS score was decreased and MRC sumscore was increased and both were improved in all patients at M12, respectively at M6 ONLS mean score 3 (range 0-8) MRC sumscore 118.4/140 (77-140), at M12 ONLS mean score 2.75 (range 0-7) and MRC sumscore 118/140 (80-140). Significant recovery in ENMG patterns nerve was observed in all patients on ulnar and median nerves including motor conduction velocities, distal CMAP amplitudes and sensory conduction velocities with respective change in between before treatment and M12 of 34.41 vs 45.47 m/s, (p CONCLUSIONS: Auto-PBSCT in POEMS syndrome results to obvious both clinical and electrophysiological improvement of peripheral neuropathy within one year after treatment, which could be assume through extensive remyelinisation and axonal regeneration. Disclosure: Dr. Gronier has nothing to disclose. Dr. Delmont has nothing to disclose. Dr. Legros has nothing to disclose. Dr. Launey has nothing to disclose. Dr. Jeandel has nothing to disclose. Dr. Fuzibet has nothing to disclose. Dr. Desnuelle has nothing to disclose." @default.
- W95574488 created "2016-06-24" @default.
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- W95574488 date "2013-02-12" @default.
- W95574488 modified "2023-09-23" @default.
- W95574488 title "Efficacy of Autologous Peripheral Blood Stem Cell Transplantation (Auto-PBSCT) on the Neuropathic Manifestations in POEMS Syndrome (P01.147)" @default.
- W95574488 hasPublicationYear "2013" @default.
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