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- W95575372 abstract "This chapter reviews the historical and current thinking on both clinical and etiological heterogeneity in schizophrenia. The diagnosis of schizophrenia is made solely on the basis of signs and symptoms; there are no laboratory tests or imaging techniques that can be used to establish the presence or absence of the disorder. Therefore, the signs and symptoms used to define schizophrenia play a critical role in clinical practice and research. Considerable variability has been observed in virtually any domain in which schizophrenia has been examined, including the age of onset, clinical characteristics, treatment response, and course. The traditional approaches to specifying subtypes of schizophrenia were based on clinical features and the course of illness. Langfeldt subdivided individuals with schizophrenia into process and reactive categories. Process (chronic) schizophrenia referred to individuals with a slow insidious onset and an unremitting course, whereas reactive (acute) schizophrenia referred to individuals with the rapid onset and periods of remission. Studies have also demonstrated that genetic factors play an important role in the etiology of schizophrenia, with an estimation of the broad heritability to be about 67%. The fact that no single genetic model provides a good fit to the observed patterns in families has also led to the suggestion that schizophrenia is etiologically heterogenous." @default.
- W95575372 created "2016-06-24" @default.
- W95575372 creator A5044176155 @default.
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- W95575372 date "2000-01-01" @default.
- W95575372 modified "2023-09-25" @default.
- W95575372 title "Chapter 13 Heterogeneity of schizophrenia" @default.
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- W95575372 doi "https://doi.org/10.1016/s1569-2582(00)80015-x" @default.
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