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- W955763586 abstract "2436 Objectives 3D-OSEM (3D) algorithms have been reported to preserve image quality in half-time myocardial perfusion imaging (MPI). Alternatively, this technique could be used to compensate for the reduced counts collected when imaging patients injected with half of the standard dose, thereby reducing radiation exposure. The objective of this phantom study is to simulate half-dose imaging utilizing the nature of the 6 hour half-life of Tc-99m. Methods A dual head gamma camera was used to acquire SPECT scans of a phantom with a cardiac defect. A simulated 30mCi dose of sestamibi was used. The phantom was imaged at time 0 (T0) and again 6 hours later (T6). Projections were reconstructed using filtered back projection (FBP) and 3D. Corridor4DM (4DM) was used to quantify the cardiac defect, calculating the defect size (Ext), in percentage of the myocardium, and the severity (Sev), in standard deviations below a normal database threshold. General image quality was assessed visually. Results 4DM results showed an increase in Ext between T0 and T6 FBP reconstructions. 3D reconstructions at T0 and T6 demonstrate a small increase in Ext when compared to T0 FBP. Both FBP and 3D reconstructions showed a minimal increase in Sev from T0 to T6. Visually, the defect is well characterized across all reconstructions. T6 FBP images appear less uniform in normal cardiac regions and appear slightly distorted in the apical and basal lateral regions, contributing to the enlarged defect Ext. These regions appear more uniform in T6 3D images. Conclusions Although subtle, image degradation as visualized in T6 FBP images adversely affects quantitative analysis, exaggerating Ext when compared to T0 FBP. Although 3D reconstructions produce slightly larger Ext values, compared to T0 FBP, the values are more consistent between T0 and T6. Furthermore, 3D appears to preserve general image quality in the low-count T6 data" @default.
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- W955763586 date "2011-05-01" @default.
- W955763586 modified "2023-09-24" @default.
- W955763586 title "A phantom study to simulate half-dose imaging in myocardial perfusion SPECT" @default.
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