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- W95589006 abstract "The objectives of a drug interaction program are to determine whether there are interactions with an NME (new molecular entity) that necessitate a dose adjustment of the NME or other drugs that it might be used with, or whether an interaction requires a contraindication or special precautions. The program should begin early in drug development so the clinical implications of interactions can be assessed adequately in clinical studies. It is important that all studies are conducted using rigorous scientific procedures. The clinical significance of interactions should be assessed based on exposure-response knowledge of the affected drug. Drug labels need to include complete information about the potential for drug interactions, including instructions for dose adjustments and special monitoring or precautions." @default.
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- W95589006 date "2011-01-01" @default.
- W95589006 modified "2023-10-14" @default.
- W95589006 title "Drug Interaction Considerations Throughout Drug Development" @default.
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- W95589006 doi "https://doi.org/10.1007/978-1-61779-213-7_18" @default.
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