Matches in SemOpenAlex for { <https://semopenalex.org/work/W95597603> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W95597603 abstract "Guanylyl cyclase C (GCC), the receptor for diarrheagenic bacterial heat-stable enterotoxins (STs) and the endogenous ligands guanylin and uroguanylin, is specifically expressed in apical membranes of intestinal epithelial cells where it regulates fluid and electrolyte secretion. However, a novel paradigm is emerging in which GCC signaling regulates the proliferation of human colon carcinoma cells. Here, the role of GCC in regulating enterocyte dynamics along the crypt-villus axis was examined. GCC target-inactivated (GCC−/−) mice exhibit elongated crypts from the duodenum to the colon, populated by more rapidly cycling progenitor cells. Further, enterocytes exhibited increased rates of migration and apoptosis, but decreased differentiation, along the crypt-villus axis of GCC−/− mice. Moreover, activation of GCC reduced proliferation of cells in human normal colonic mucosa obtained from patients and inhibited cell cycle progression of NCM460 human colonic crypt cells. Indeed, GCC delayed G1/S cell cycle transition which was mediated by cGMP-dependent protein kinase. These data demonstrate that GCC contributes to the homeostatic transition from proliferation to differentiation along the intestinal crypt-villus axis. Since expression of the endogenous ligands is frequently lost during colorectal carcinogenesis, GCC may represent a novel intestinal tumor suppressor." @default.
- W95597603 created "2016-06-24" @default.
- W95597603 creator A5022300126 @default.
- W95597603 creator A5022471130 @default.
- W95597603 creator A5036674274 @default.
- W95597603 creator A5053056193 @default.
- W95597603 creator A5062664304 @default.
- W95597603 creator A5087765283 @default.
- W95597603 date "2006-03-01" @default.
- W95597603 modified "2023-09-26" @default.
- W95597603 title "Guanylyl Cyclase C Regulates the Intestinal Crypt‐Villus Axis" @default.
- W95597603 doi "https://doi.org/10.1096/fasebj.20.5.a1129-c" @default.
- W95597603 hasPublicationYear "2006" @default.
- W95597603 type Work @default.
- W95597603 sameAs 95597603 @default.
- W95597603 citedByCount "0" @default.
- W95597603 crossrefType "journal-article" @default.
- W95597603 hasAuthorship W95597603A5022300126 @default.
- W95597603 hasAuthorship W95597603A5022471130 @default.
- W95597603 hasAuthorship W95597603A5036674274 @default.
- W95597603 hasAuthorship W95597603A5053056193 @default.
- W95597603 hasAuthorship W95597603A5062664304 @default.
- W95597603 hasAuthorship W95597603A5087765283 @default.
- W95597603 hasConcept C126322002 @default.
- W95597603 hasConcept C13121076 @default.
- W95597603 hasConcept C134018914 @default.
- W95597603 hasConcept C170493617 @default.
- W95597603 hasConcept C185592680 @default.
- W95597603 hasConcept C201750760 @default.
- W95597603 hasConcept C2777882243 @default.
- W95597603 hasConcept C2779604457 @default.
- W95597603 hasConcept C2780069284 @default.
- W95597603 hasConcept C28328180 @default.
- W95597603 hasConcept C3019368612 @default.
- W95597603 hasConcept C55493867 @default.
- W95597603 hasConcept C62112901 @default.
- W95597603 hasConcept C62478195 @default.
- W95597603 hasConcept C66090201 @default.
- W95597603 hasConcept C71924100 @default.
- W95597603 hasConcept C86803240 @default.
- W95597603 hasConcept C95444343 @default.
- W95597603 hasConceptScore W95597603C126322002 @default.
- W95597603 hasConceptScore W95597603C13121076 @default.
- W95597603 hasConceptScore W95597603C134018914 @default.
- W95597603 hasConceptScore W95597603C170493617 @default.
- W95597603 hasConceptScore W95597603C185592680 @default.
- W95597603 hasConceptScore W95597603C201750760 @default.
- W95597603 hasConceptScore W95597603C2777882243 @default.
- W95597603 hasConceptScore W95597603C2779604457 @default.
- W95597603 hasConceptScore W95597603C2780069284 @default.
- W95597603 hasConceptScore W95597603C28328180 @default.
- W95597603 hasConceptScore W95597603C3019368612 @default.
- W95597603 hasConceptScore W95597603C55493867 @default.
- W95597603 hasConceptScore W95597603C62112901 @default.
- W95597603 hasConceptScore W95597603C62478195 @default.
- W95597603 hasConceptScore W95597603C66090201 @default.
- W95597603 hasConceptScore W95597603C71924100 @default.
- W95597603 hasConceptScore W95597603C86803240 @default.
- W95597603 hasConceptScore W95597603C95444343 @default.
- W95597603 hasIssue "5" @default.
- W95597603 hasLocation W955976031 @default.
- W95597603 hasOpenAccess W95597603 @default.
- W95597603 hasPrimaryLocation W955976031 @default.
- W95597603 hasRelatedWork W2040015116 @default.
- W95597603 hasRelatedWork W2093529631 @default.
- W95597603 hasRelatedWork W2111214065 @default.
- W95597603 hasRelatedWork W2151027247 @default.
- W95597603 hasRelatedWork W2336243119 @default.
- W95597603 hasRelatedWork W2370243700 @default.
- W95597603 hasRelatedWork W2757774411 @default.
- W95597603 hasRelatedWork W2901254075 @default.
- W95597603 hasRelatedWork W2948963429 @default.
- W95597603 hasRelatedWork W95597603 @default.
- W95597603 hasVolume "20" @default.
- W95597603 isParatext "false" @default.
- W95597603 isRetracted "false" @default.
- W95597603 magId "95597603" @default.
- W95597603 workType "article" @default.