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- W956039009 abstract "This chapter presents and discusses different strategies to dissect genetically the molecular mechanisms of Alzheimer’s disease. First, a short preamble sketches the common phenotypical features of Alzheimer’s disease. Second, a basic introduction defines the characteristics of a good animal model along with the different molecular strategies commonly used to develop transgenic animals. Third, an exclusive census of genetically modified mouse models describes some of the remarkable characteristics observed in these animals and tries to weigh the pros and cons of each of them. Finally, a brief note highlights gene-environment interactions relevant to the field of genetic mouse models and Alzheimer’s disease. All sections are illustrated with examples focusing on behavioral phenotypes with a specific interest on learning and memory.Key WordsAlzheimer’s diseaseTransgenicMouse modelsNeuroanatomyBehaviorLearningMemoryAmyloidSecretasesTau" @default.
- W956039009 created "2016-06-24" @default.
- W956039009 creator A5051344288 @default.
- W956039009 date "2008-03-06" @default.
- W956039009 modified "2023-09-25" @default.
- W956039009 title "Genetic Models of Alzheimer’s Disease" @default.
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- W956039009 doi "https://doi.org/10.1007/978-1-59745-285-4_55" @default.
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