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- W956467488 abstract "DNA double-strand breaks (DSBs) are often targeted to nuclear pore complexes (NPCs) for repair. How targeting is achieved and the DNA repair pathways involved in this process remain unclear. Here, we show that the kinesin-14 motor protein complex (Cik1-Kar3) cooperates with chromatin remodellers to mediate interactions between subtelomeric DSBs and the Nup84 nuclear pore complex to ensure cell survival via break-induced replication (BIR), an error-prone DNA repair process. Insertion of a DNA zip code near the subtelomeric DSB site artificially targets it to NPCs hyperactivating this repair mechanism. Kinesin-14 and Nup84 mediate BIR-dependent repair at non-telomeric DSBs whereas perinuclear telomere tethers are only required for telomeric BIR. Furthermore, kinesin-14 plays a critical role in telomerase-independent telomere maintenance. Thus, we uncover roles for kinesin and NPCs in DNA repair by BIR and reveal that perinuclear telomere anchors license subtelomeric DSBs for this error-prone DNA repair mechanism." @default.
- W956467488 created "2016-06-24" @default.
- W956467488 creator A5010501938 @default.
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- W956467488 date "2015-07-24" @default.
- W956467488 modified "2023-09-26" @default.
- W956467488 title "Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process" @default.
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- W956467488 doi "https://doi.org/10.1038/ncomms8742" @default.
- W956467488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26205667" @default.
- W956467488 hasPublicationYear "2015" @default.
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