Matches in SemOpenAlex for { <https://semopenalex.org/work/W956579504> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W956579504 abstract "Tracking cell migration in vivo by scintigraphy using cells labelled with gamma-emitting radionuclides (especially indium-111) is a well-established clinical and research tool. Positron emission tomography offers improved sensitivity and resolution, but there are no established cell labelling methods using suitable long-lived isotopes. The long half-life positron emitter zirconium-89 (half-life 78.4 h) is a strong candidate for cell labelling and cell tracking, and is becoming increasingly available. It has no known biological role or transport mechanisms. The aim of this research was to produce a range of candidate neutral zirconium L4 lipophilic complexes that could be prepared under radiopharmaceutical conditions and used in cell labelling. This aim was achieved with the ligands; oxine, tropolone and ethyl maltol. The resulting complexes can be prepared in high yield from zirconium precursors in hydrochloric or oxalic acid solution. A deferiprone complex was prepared from deferiprone and zirconium tetrachloride, but was found to lack lipophilic properties and it was not possible to prepare the deferiprone complex under radiopharmaceutical conditions.Analytical techniques such as carbon, hydrogen and nitrogen elemental analysis, nuclear magnetic resonance spectroscopy, fourier transform infrared spectroscopy, and Raman spectroscopy have been used to characterise the complexes. The oxine and tropolone complexes were the most amenable to chromatographic characterisation and high performance liquid chromatography and instant thin layer chromatography protocols have been established to monitor radiochemical purity.Cell uptake and efflux of zirconium-89 tetrakisoxine, tropolone and ethyl maltol utilising the following cell lines was determined; HCT116: colon cancer, J774: mouse macrophage and MDA-MB-231: breast cancer. Zirconium-89 tetrakisoxine has emerged as a lead compound. Zirconium-89 tetrakisoxine labelled myeloma cells retained the radiotracer in vivo for up to 7 days. Zirconium-89 tetrakisoxine was found to be a promising cell tracking agent for long term cell tracking studies." @default.
- W956579504 created "2016-06-24" @default.
- W956579504 creator A5046770925 @default.
- W956579504 date "2015-04-01" @default.
- W956579504 modified "2023-09-27" @default.
- W956579504 title "Zirconium-89 complexes for cell tracking with positron emission tomography" @default.
- W956579504 cites W1518053547 @default.
- W956579504 cites W1518684029 @default.
- W956579504 cites W1536797237 @default.
- W956579504 cites W1539778282 @default.
- W956579504 cites W1569113399 @default.
- W956579504 cites W1596406131 @default.
- W956579504 cites W1599077860 @default.
- W956579504 cites W1660190908 @default.
- W956579504 cites W1984969847 @default.
- W956579504 cites W2024484939 @default.
- W956579504 cites W2096992930 @default.
- W956579504 cites W2112531993 @default.
- W956579504 cites W2345285085 @default.
- W956579504 cites W2489010519 @default.
- W956579504 cites W2497013960 @default.
- W956579504 cites W2506632557 @default.
- W956579504 cites W2506761063 @default.
- W956579504 cites W25162899 @default.
- W956579504 cites W2895359464 @default.
- W956579504 cites W3143036212 @default.
- W956579504 cites W585276791 @default.
- W956579504 cites W609687340 @default.
- W956579504 cites W647101430 @default.
- W956579504 hasPublicationYear "2015" @default.
- W956579504 type Work @default.
- W956579504 sameAs 956579504 @default.
- W956579504 citedByCount "0" @default.
- W956579504 crossrefType "dissertation" @default.
- W956579504 hasAuthorship W956579504A5046770925 @default.
- W956579504 hasConcept C13965031 @default.
- W956579504 hasConcept C177322064 @default.
- W956579504 hasConcept C178790620 @default.
- W956579504 hasConcept C179104552 @default.
- W956579504 hasConcept C185592680 @default.
- W956579504 hasConcept C2777509971 @default.
- W956579504 hasConcept C534791751 @default.
- W956579504 hasConceptScore W956579504C13965031 @default.
- W956579504 hasConceptScore W956579504C177322064 @default.
- W956579504 hasConceptScore W956579504C178790620 @default.
- W956579504 hasConceptScore W956579504C179104552 @default.
- W956579504 hasConceptScore W956579504C185592680 @default.
- W956579504 hasConceptScore W956579504C2777509971 @default.
- W956579504 hasConceptScore W956579504C534791751 @default.
- W956579504 hasLocation W9565795041 @default.
- W956579504 hasOpenAccess W956579504 @default.
- W956579504 hasPrimaryLocation W9565795041 @default.
- W956579504 hasRelatedWork W1892458967 @default.
- W956579504 hasRelatedWork W1988760858 @default.
- W956579504 hasRelatedWork W2026189147 @default.
- W956579504 hasRelatedWork W2060146981 @default.
- W956579504 hasRelatedWork W2060587311 @default.
- W956579504 hasRelatedWork W2080348047 @default.
- W956579504 hasRelatedWork W2178895009 @default.
- W956579504 hasRelatedWork W2731086658 @default.
- W956579504 hasRelatedWork W2764037785 @default.
- W956579504 hasRelatedWork W2767081692 @default.
- W956579504 hasRelatedWork W2943546486 @default.
- W956579504 hasRelatedWork W1596271617 @default.
- W956579504 hasRelatedWork W2149394543 @default.
- W956579504 hasRelatedWork W2346136422 @default.
- W956579504 hasRelatedWork W2786012017 @default.
- W956579504 hasRelatedWork W2959036076 @default.
- W956579504 hasRelatedWork W3146462803 @default.
- W956579504 isParatext "false" @default.
- W956579504 isRetracted "false" @default.
- W956579504 magId "956579504" @default.
- W956579504 workType "dissertation" @default.