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- W95672616 abstract "With a prevalence of about 5/100.000, progressive supranuclear palsy is one of the most frequent tauopathies. Clinically, PSP is characterized by early occurrence of severe postural instability and consecutive falls, supranuclear gaze palsy, axial rigidity, dysphagia, and levodopa unresponsiveness. Approximately half of patients develop cognitive symptoms, mostly executive dysfunction and neurobehavioral signs like apathy and disinhibition. These symptoms are associated with degeneration of cholinergic circuits. Cognitive changes are more severe than in Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy, and corticobasal degeneration. Neuropsychological tests and imaging methods can be helpful diagnostic tools. Cholinesterase inhibitors and even levodopa can improve cognitive symptoms. New disease-modifying therapies targeting dysfunctional tau or mitochondrial dysfunction are promising." @default.
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- W95672616 date "2015-01-01" @default.
- W95672616 modified "2023-10-17" @default.
- W95672616 title "Progressive Supranuclear Palsy and Dementia" @default.
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