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- W956828652 abstract "Hypotheses of a relationship between functional abnormalities of CNS neurotransmitters such as norepinephrine (NE), dopamine (DA) or 5-hydroxytryptamine (5-HT, serotonin), and depressive disorders have been advanced by inductive reasoning based on pharmacologic studies in animals (Bunney and Davis, 1975; Schildkraut and Kety, 1967; Goodwin and Murphy, 1974). Within this conceptional framework antidepressant drugs such as the “tricyclics” and the monoamine oxidase (MAO) inhibitors have been extensively studied with regard to their effects on the neurotransmitter systems mentioned above. It has been shown that tricyclic antidepressants inhibit the uptake of NE and 5-HT into respective neurons (Carlsson, 1965). Further differentiation of the pharmacologic effects revealed that tricyclic antidepressants with terminal tertiary amines (e.g., imipramine, amitriptyline, chlorimipramine) affected reuptake of mainly 5-HT. Their desmethylated metabolites, the secondary amines desmethylimipramine, nortriptyline, and desmethylchlorimipramine, were found to inhibit predominantly NE uptake (for review, Maas, 1975). To what extent the clinical effects of tricyclics are indeed contingent on uptake inhibition of respective neurotransmitters, whether the concommitant MAO inhibitory effects might also play a role (Roth, 1976), or whether both biochemical properties are merely secondarily related to the therapeutic effect are still an unresolved question. The absence of a valid animal model of human depression renders the necessary test of the validity of any pharmacologic hypothesis in man extremely difficult." @default.
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- W956828652 date "1980-01-01" @default.
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- W956828652 title "Biochemical Effects of Antidepressants in Man" @default.
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- W956828652 doi "https://doi.org/10.1007/978-3-642-67538-6_22" @default.
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