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- W95695015 abstract "Voltage-dependent K+ channels are the intrinsic membrane proteins that draw the cell resting potential toward K+ equilibrium potential by forming a conduction pathway, or pore, through which K+ selectively diffuses down the electrochemical gradient across the membrane. The voltage imposed across the cell membrane governs pore opening, hence the name voltage-dependent K+ channels. These channels serve as the appropriate negative feedback to excitatory inputs on a cell when they are active by hyperpolarizing the cell membrane. In general, voltage-dependent K+ channels increase their activity on membrane depolarization, this activation dampens the excitatory events that depolarize the cell membrane and/or elevate the cytosolic Ca2+. Voltage-dependent K+ channels are widely distributed in mammalian tissues and play important physiological roles. Some of the roles that voltage-dependent K+ channels play include setting the duration of action potentials and the interspike interval during repetitive firing in neurons and in the heart, secreting K+ in epithelia, setting the smooth muscle tone, and determining the resonance frequency in hair cells. Voltage-dependent K+ channels are made of subunits that assemble in the bilayer as tetramers to form highly selective K+ channels. The tremendous diversity of voltage-dependent K+ channels can be attributed to the large number of different genes present, alternative splicing, auxiliary β-subunits, and metabolic regulation." @default.
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- W95695015 date "2013-01-01" @default.
- W95695015 modified "2023-10-03" @default.
- W95695015 title "Voltage-Dependent K+ Channels" @default.
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- W95695015 doi "https://doi.org/10.1016/b978-0-12-378630-2.00144-4" @default.
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