Matches in SemOpenAlex for { <https://semopenalex.org/work/W95711210> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W95711210 abstract "Background: Genetic variations in the CACNB2 gene, which encodes a regulatory subunit of the L-type calcium channel, have not been thoroughly characterized. We undertook a single nucleotide polymorphism (SNP) discovery effort to characterize SNPs in CACNB2 and to determine if these SNPs were associated with adverse cardiovascular outcomes in patients with hypertension and coronary artery disease (CAD), and if associated, to determine functional underpinnings. Methods: Genomic DNA from 60 ethnically diverse individuals was used for SNP discovery. SNPs from exons, intron/exon junctions, 5′ and 3′UTR of CACNB2 were identified and characterized by direct DNA sequencing. Four common SNPs (rs12764271, rs7069292, rs16917273, and rs2357928) from the 14 SNPs that were predicted to be functional by PolyMApr, were selected for a clinical association study in 1032 hypertensive CAD patients in INVEST-GENES who were randomized to atenolol or verapamil-SR-based treatment. Reporter assays were performed in CHO and HEK293..." @default.
- W95711210 created "2016-06-24" @default.
- W95711210 creator A5004217701 @default.
- W95711210 creator A5048554505 @default.
- W95711210 creator A5054191921 @default.
- W95711210 creator A5061196407 @default.
- W95711210 creator A5061865147 @default.
- W95711210 creator A5065188755 @default.
- W95711210 creator A5088669682 @default.
- W95711210 date "2008-10-28" @default.
- W95711210 modified "2023-09-26" @default.
- W95711210 title "Abstract 4414: DNA Variations in Voltage-gated Calcium Channel Beta 2 Subunit (CACNB2) Gene, Functional Consequences, and Association with Adverse Cardiovascular Outcomes in the INternational VErapamil SR-trandolapril STudy-GENEtic Substudy" @default.
- W95711210 hasPublicationYear "2008" @default.
- W95711210 type Work @default.
- W95711210 sameAs 95711210 @default.
- W95711210 citedByCount "0" @default.
- W95711210 crossrefType "journal-article" @default.
- W95711210 hasAuthorship W95711210A5004217701 @default.
- W95711210 hasAuthorship W95711210A5048554505 @default.
- W95711210 hasAuthorship W95711210A5054191921 @default.
- W95711210 hasAuthorship W95711210A5061196407 @default.
- W95711210 hasAuthorship W95711210A5061865147 @default.
- W95711210 hasAuthorship W95711210A5065188755 @default.
- W95711210 hasAuthorship W95711210A5088669682 @default.
- W95711210 hasConcept C104317684 @default.
- W95711210 hasConcept C106208931 @default.
- W95711210 hasConcept C126322002 @default.
- W95711210 hasConcept C135763542 @default.
- W95711210 hasConcept C139275648 @default.
- W95711210 hasConcept C153209595 @default.
- W95711210 hasConcept C36823959 @default.
- W95711210 hasConcept C54355233 @default.
- W95711210 hasConcept C60644358 @default.
- W95711210 hasConcept C69991583 @default.
- W95711210 hasConcept C71924100 @default.
- W95711210 hasConcept C86803240 @default.
- W95711210 hasConcept C98274493 @default.
- W95711210 hasConceptScore W95711210C104317684 @default.
- W95711210 hasConceptScore W95711210C106208931 @default.
- W95711210 hasConceptScore W95711210C126322002 @default.
- W95711210 hasConceptScore W95711210C135763542 @default.
- W95711210 hasConceptScore W95711210C139275648 @default.
- W95711210 hasConceptScore W95711210C153209595 @default.
- W95711210 hasConceptScore W95711210C36823959 @default.
- W95711210 hasConceptScore W95711210C54355233 @default.
- W95711210 hasConceptScore W95711210C60644358 @default.
- W95711210 hasConceptScore W95711210C69991583 @default.
- W95711210 hasConceptScore W95711210C71924100 @default.
- W95711210 hasConceptScore W95711210C86803240 @default.
- W95711210 hasConceptScore W95711210C98274493 @default.
- W95711210 hasLocation W957112101 @default.
- W95711210 hasOpenAccess W95711210 @default.
- W95711210 hasPrimaryLocation W957112101 @default.
- W95711210 hasRelatedWork W1509995325 @default.
- W95711210 hasRelatedWork W1832350141 @default.
- W95711210 hasRelatedWork W1974007339 @default.
- W95711210 hasRelatedWork W1995846502 @default.
- W95711210 hasRelatedWork W1999192185 @default.
- W95711210 hasRelatedWork W2015650646 @default.
- W95711210 hasRelatedWork W2018291025 @default.
- W95711210 hasRelatedWork W2053325688 @default.
- W95711210 hasRelatedWork W2061200315 @default.
- W95711210 hasRelatedWork W2075786752 @default.
- W95711210 hasRelatedWork W2090172062 @default.
- W95711210 hasRelatedWork W2124001412 @default.
- W95711210 hasRelatedWork W2409122371 @default.
- W95711210 hasRelatedWork W2883570063 @default.
- W95711210 hasRelatedWork W2889857757 @default.
- W95711210 hasRelatedWork W2981909786 @default.
- W95711210 hasRelatedWork W3052406843 @default.
- W95711210 hasRelatedWork W3108380029 @default.
- W95711210 hasRelatedWork W3163715263 @default.
- W95711210 hasRelatedWork W3186878312 @default.
- W95711210 hasVolume "118" @default.
- W95711210 isParatext "false" @default.
- W95711210 isRetracted "false" @default.
- W95711210 magId "95711210" @default.
- W95711210 workType "article" @default.