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- W957433008 abstract "Ganglioside GM3 is the major ganglioside component in erythrocytes of many animal species. In addition to the known biological functions of GM3, much attention has been focused on ganglioside GM3 and its degradation products because of their involvement in cell proliferation, differentiation, oncogenesis, and modulation of transmembrane signaling. Ganglioside GM3 has also been found to be a potential immunosuppressor and a substrate of the trans-sialidase of Trypanosoma cruzi. In view of these facts, it is of interest to investigate the relationship between the structures of sialic acid and ceramide moieties and the biological functions of GM3 at the molecular level. This chapter describes a facile, preparative synthesis not only of natural ganglioside GM3 but also of various types of analogs containing a variety of modified sialic acids and ceramides." @default.
- W957433008 created "2016-06-24" @default.
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- W957433008 date "1994-01-01" @default.
- W957433008 modified "2023-10-18" @default.
- W957433008 title "[16] Synthesis of ganglioside GM3 and analogs containing modified sialic acids and ceramides" @default.
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- W957433008 doi "https://doi.org/10.1016/0076-6879(94)42018-1" @default.
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