Matches in SemOpenAlex for { <https://semopenalex.org/work/W9576541> ?p ?o ?g. }
- W9576541 endingPage "326" @default.
- W9576541 startingPage "305" @default.
- W9576541 abstract "The structural protein, β-tubulin is the target for a number of anti-mitotic compounds that bind to and inhibit microtubule dynamics, leading to apoptosis in all dividing cells. The existence of several isotypes of β-tubulin, coupled with their varied distribution throughout different organisms provides a platform upon which to construct novel agents, which are able to differentiate between cell types. Several examples of compounds that perturb microtubule dynamics, such as paclitaxel, are currently some of the most effective drugs used in cancer chemotherapy. Additionally, MT disrupting agents such as the dinitroanilines, disrupt plant but not animal microtubules and are therefore useful herbicides. However, even with their wide use and important function, the method of action of MT disrupting compounds is unknown. We have performed homology modeling on approximately 500 α- and β-tubulin sequences and identified an expected global, structural similarity of tubulin monomers. We have been able to calculate discernable differences in several properties, including their net electric charge, volume, surface area, electric dipole moment and dipole vector orientation. These are properties that may influence the functional characteristics of individual tubulin monomers, thereby resulting in a global effect on microtubule stability and assembly kinetics." @default.
- W9576541 created "2016-06-24" @default.
- W9576541 creator A5020627671 @default.
- W9576541 creator A5034385881 @default.
- W9576541 creator A5078976974 @default.
- W9576541 creator A5082024795 @default.
- W9576541 date "2009-06-30" @default.
- W9576541 modified "2023-09-26" @default.
- W9576541 title "Tubulin Isotypes And Their Role In Microtubule Dynamic Instability, Implications For Modeling And Rational Design Of Inhibitors" @default.
- W9576541 cites W1508885706 @default.
- W9576541 cites W1553969220 @default.
- W9576541 cites W1568415783 @default.
- W9576541 cites W1913492258 @default.
- W9576541 cites W1962536161 @default.
- W9576541 cites W1963878289 @default.
- W9576541 cites W1966309233 @default.
- W9576541 cites W1971579914 @default.
- W9576541 cites W1982485940 @default.
- W9576541 cites W1982977272 @default.
- W9576541 cites W1994345832 @default.
- W9576541 cites W2002742784 @default.
- W9576541 cites W2007094590 @default.
- W9576541 cites W2009772522 @default.
- W9576541 cites W2012317077 @default.
- W9576541 cites W2016776801 @default.
- W9576541 cites W2019459311 @default.
- W9576541 cites W2019721152 @default.
- W9576541 cites W2023936614 @default.
- W9576541 cites W2026573286 @default.
- W9576541 cites W2027071679 @default.
- W9576541 cites W2029582401 @default.
- W9576541 cites W2037490361 @default.
- W9576541 cites W2043478531 @default.
- W9576541 cites W2046655465 @default.
- W9576541 cites W2048188756 @default.
- W9576541 cites W2050285145 @default.
- W9576541 cites W2054341244 @default.
- W9576541 cites W2058997498 @default.
- W9576541 cites W2060232338 @default.
- W9576541 cites W2064571598 @default.
- W9576541 cites W2064693294 @default.
- W9576541 cites W2069400786 @default.
- W9576541 cites W2071217596 @default.
- W9576541 cites W2075499553 @default.
- W9576541 cites W2075734600 @default.
- W9576541 cites W2075893848 @default.
- W9576541 cites W2076659391 @default.
- W9576541 cites W2079655651 @default.
- W9576541 cites W2081406767 @default.
- W9576541 cites W2086526874 @default.
- W9576541 cites W2092697567 @default.
- W9576541 cites W2094031081 @default.
- W9576541 cites W2097729800 @default.
- W9576541 cites W2108508060 @default.
- W9576541 cites W2111496441 @default.
- W9576541 cites W2122741144 @default.
- W9576541 cites W2123369384 @default.
- W9576541 cites W2123768693 @default.
- W9576541 cites W2128050586 @default.
- W9576541 cites W2131961997 @default.
- W9576541 cites W2132498273 @default.
- W9576541 cites W2140197466 @default.
- W9576541 cites W2148853951 @default.
- W9576541 cites W2151387311 @default.
- W9576541 cites W2163389258 @default.
- W9576541 cites W2169640068 @default.
- W9576541 cites W2171219367 @default.
- W9576541 cites W2171546216 @default.
- W9576541 cites W2172831970 @default.
- W9576541 cites W2320462286 @default.
- W9576541 cites W233135433 @default.
- W9576541 cites W243427647 @default.
- W9576541 cites W3191847295 @default.
- W9576541 cites W4292079585 @default.
- W9576541 cites W4302374972 @default.
- W9576541 doi "https://doi.org/10.1007/978-1-4020-8843-8_15" @default.
- W9576541 hasPublicationYear "2009" @default.
- W9576541 type Work @default.
- W9576541 sameAs 9576541 @default.
- W9576541 citedByCount "0" @default.
- W9576541 crossrefType "book-chapter" @default.
- W9576541 hasAuthorship W9576541A5020627671 @default.
- W9576541 hasAuthorship W9576541A5034385881 @default.
- W9576541 hasAuthorship W9576541A5078976974 @default.
- W9576541 hasAuthorship W9576541A5082024795 @default.
- W9576541 hasConcept C121608353 @default.
- W9576541 hasConcept C12554922 @default.
- W9576541 hasConcept C185592680 @default.
- W9576541 hasConcept C20418707 @default.
- W9576541 hasConcept C2777292972 @default.
- W9576541 hasConcept C53105671 @default.
- W9576541 hasConcept C54355233 @default.
- W9576541 hasConcept C70721500 @default.
- W9576541 hasConcept C84425145 @default.
- W9576541 hasConcept C86803240 @default.
- W9576541 hasConcept C95444343 @default.
- W9576541 hasConceptScore W9576541C121608353 @default.
- W9576541 hasConceptScore W9576541C12554922 @default.