FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W957673685> ?p ?o ?g. }

• W957673685 endingPage "223" @default.
• W957673685 startingPage "214" @default.
• W957673685 abstract "Escherichia coli is one of the most frequent causes of many common bacterial infections, including cholecystitis, bacteremia, cholangitis, urinary tract infection (UTI), traveler's diarrhea and other clinical infections such as neonatal meningitis and pneumonia. The fatty acid biosynthesis is essential for the bacterial viability and growth. There are three types of β-ketoacyl acyl carrier protein synthase (KAS) which are important for overcoming the bacterial resistance problem. β-ketoacyl acyl carrier protein synthase I (KAS I) is member of the condensing enzyme family, which is a key catalyst in bacterial fatty acid biosynthesis, and thus an attractive target for novel antibioticsis related to the elongation of unsaturated fatty acids in bacterial fatty acid synthesis and can be a good therapeutic target of designing novel antibiotics. In this report, we performed docking study of E. coli (KAS I) and 50 flavonoids. Out of these 50 flavonoids, there are two compounds, genistein and isorhamnetin, that showed the superior binding energy while fully satisfying the conditions of drug likeliness. The predicted binding energy of genistein and isorhamnetin toward KAS I are -135.76kcal/mol and -132.42kcal/mol, respectively. These energies favorably compare to the biding energy of known drugs thiolactomicin and cerulenin that are -90.26kcal/mol and -99.64kcal/mol, respectively. The method used was docking with the selected E. coli (KAS I-PDB ID-1FJ4) using iGemdock. This was also found to obey the Lipinski's guidelines of five and to show the drug likeliness and bioavailability." @default.
• W957673685 created "2016-06-24" @default.
• W957673685 creator A5013779276 @default.
• W957673685 creator A5050753047 @default.
• W957673685 date "2015-09-01" @default.
• W957673685 modified "2023-09-27" @default.
• W957673685 title "Docking studies of flavonoid compounds as inhibitors of β-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli" @default.
• W957673685 cites W1531359882 @default.
• W957673685 cites W1541294208 @default.
• W957673685 cites W1967949689 @default.
• W957673685 cites W1968068275 @default.
• W957673685 cites W1972807408 @default.
• W957673685 cites W1973085271 @default.
• W957673685 cites W1974937868 @default.
• W957673685 cites W1980574342 @default.
• W957673685 cites W1985378557 @default.
• W957673685 cites W1997919366 @default.
• W957673685 cites W2004098285 @default.
• W957673685 cites W2014931634 @default.
• W957673685 cites W2021348656 @default.
• W957673685 cites W2029256626 @default.
• W957673685 cites W2038053883 @default.
• W957673685 cites W2040318221 @default.
• W957673685 cites W2058248134 @default.
• W957673685 cites W2058265502 @default.
• W957673685 cites W2064746154 @default.
• W957673685 cites W2075972305 @default.
• W957673685 cites W2076452367 @default.
• W957673685 cites W2077465635 @default.
• W957673685 cites W2078792117 @default.
• W957673685 cites W2078870510 @default.
• W957673685 cites W2081884703 @default.
• W957673685 cites W2092468312 @default.
• W957673685 cites W2092779137 @default.
• W957673685 cites W2097225638 @default.
• W957673685 cites W2104478003 @default.
• W957673685 cites W2109941631 @default.
• W957673685 cites W2121293808 @default.
• W957673685 cites W2133033644 @default.
• W957673685 cites W2135732933 @default.
• W957673685 cites W2136567948 @default.
• W957673685 cites W2141640160 @default.
• W957673685 cites W2143028632 @default.
• W957673685 cites W2145239509 @default.
• W957673685 cites W2146177711 @default.
• W957673685 cites W2169330513 @default.
• W957673685 cites W4241169468 @default.
• W957673685 cites W4255260521 @default.
• W957673685 doi "https://doi.org/10.1016/j.jmgm.2015.07.005" @default.
• W957673685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26292066" @default.
• W957673685 hasPublicationYear "2015" @default.
• W957673685 type Work @default.
• W957673685 sameAs 957673685 @default.
• W957673685 citedByCount "22" @default.
• W957673685 countsByYear W9576736852016 @default.
• W957673685 countsByYear W9576736852017 @default.
• W957673685 countsByYear W9576736852019 @default.
• W957673685 countsByYear W9576736852020 @default.
• W957673685 countsByYear W9576736852021 @default.
• W957673685 countsByYear W9576736852022 @default.
• W957673685 countsByYear W9576736852023 @default.
• W957673685 crossrefType "journal-article" @default.
• W957673685 hasAuthorship W957673685A5013779276 @default.
• W957673685 hasAuthorship W957673685A5050753047 @default.
• W957673685 hasConcept C104317684 @default.
• W957673685 hasConcept C159110408 @default.
• W957673685 hasConcept C181199279 @default.
• W957673685 hasConcept C2776941171 @default.
• W957673685 hasConcept C2777810353 @default.
• W957673685 hasConcept C2778004101 @default.
• W957673685 hasConcept C2779054382 @default.
• W957673685 hasConcept C2780450397 @default.
• W957673685 hasConcept C2780683386 @default.
• W957673685 hasConcept C2780786045 @default.
• W957673685 hasConcept C41685203 @default.
• W957673685 hasConcept C48289651 @default.
• W957673685 hasConcept C543025807 @default.
• W957673685 hasConcept C547475151 @default.
• W957673685 hasConcept C553450214 @default.
• W957673685 hasConcept C55493867 @default.
• W957673685 hasConcept C71924100 @default.
• W957673685 hasConcept C86803240 @default.
• W957673685 hasConcept C89423630 @default.
• W957673685 hasConceptScore W957673685C104317684 @default.
• W957673685 hasConceptScore W957673685C159110408 @default.
• W957673685 hasConceptScore W957673685C181199279 @default.
• W957673685 hasConceptScore W957673685C2776941171 @default.
• W957673685 hasConceptScore W957673685C2777810353 @default.
• W957673685 hasConceptScore W957673685C2778004101 @default.
• W957673685 hasConceptScore W957673685C2779054382 @default.
• W957673685 hasConceptScore W957673685C2780450397 @default.
• W957673685 hasConceptScore W957673685C2780683386 @default.
• W957673685 hasConceptScore W957673685C2780786045 @default.
• W957673685 hasConceptScore W957673685C41685203 @default.
• W957673685 hasConceptScore W957673685C48289651 @default.
• W957673685 hasConceptScore W957673685C543025807 @default.
• W957673685 hasConceptScore W957673685C547475151 @default.
• W957673685 hasConceptScore W957673685C553450214 @default.

• next