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- W957706634 abstract "The incidence of brain metastasis is increasing, however, little is known about the molecular mechanisms responsible for metastasis of peripheral tumor cells and their colonization of the brain. After tumor cells metastasize to the brain, they encounter a completely different microenvironment from that in the periphery. The interactions between tumor cells and glial cells, mainly astrocytes and microglia, including soluble factors released from these cells, are still under investigation. However this knowledge will contribute to understanding the mechanisms of cell-cell interactions in the brain and identify possible therapeutic targets on resident brain cells that could effect brain metastasis formation and treatment. In addition to the complex interactions between metastatic tumor cells and the brain’s resident cells, factors from endothelial cells and endogenous plasma factors also affect the blood-brain barrier and may change tumor cell characteristics. Therefore the totality of the brain microenvironment must be considered. The cell types and soluble factors that contribute to the brain microenvironment surrounding metastatic tumor cells are discussed herein." @default.
- W957706634 created "2016-06-24" @default.
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- W957706634 date "2012-01-01" @default.
- W957706634 modified "2023-09-23" @default.
- W957706634 title "The Brain Microenvironment" @default.
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- W957706634 doi "https://doi.org/10.1007/978-94-007-5291-7_3" @default.
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