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- W957876478 abstract "This chapter discusses a cell culture approach to study the anterior pituitary cells. Pituitary cells maintained in vitro for months or years differ from pituitary organ cultures in which tissue organization is maintained, and from tissue culture starting from small fragments of tissue which grow and can display selection in some cell populations. Among cell cultures one must distinguish (1) primary cultures that start from normal adult fully differentiated anterior pituitary cells, and (2) continuous cell lines that consist of homogeneous populations of pituitary glandular cells which continuously grow in vitro. The chapter discusses the functional and morphological features of pituitary cells grown in these two situations. The effects on these models of factors that regulate the secretion of anterior pituitary hormones are analyzed and discussed. Anterior pituitary continuous cell lines were found to be a useful model for the analysis of mechanisms of action of agents that quantitatively regulate their hormonal secretion. In several cases they appear to be very close to the in vivo situation, e.g., control of prolactin (PRL) secretion by TSH-releasing hormone (TRH) and estrogens, control of growth hormone secretion by thyroid hormone, and control of adrenocorticotropic hormone (ACTH) secretion by glucocorticoids. Because of their cellular homogeneity, they have the advantage in regard to primary culture of allowing investigations at the molecular level, which are undergoing rapid progress." @default.
- W957876478 created "2016-06-24" @default.
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- W957876478 date "1975-01-01" @default.
- W957876478 modified "2023-09-23" @default.
- W957876478 title "A Cell Culture Approach to the Study of Anterior Pituitary Cells" @default.
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- W957876478 doi "https://doi.org/10.1016/s0074-7696(08)60968-7" @default.
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