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• W958055355 abstract "Research Article15 December 1993free access Characterization of NGG1, a novel yeast gene required for glucose repression of GAL4p-regulated transcription. C.J. Brandl C.J. Brandl Department of Biochemistry, University of Western Ontario, London, Canada. Search for more papers by this author A.M. Furlanetto A.M. Furlanetto Department of Biochemistry, University of Western Ontario, London, Canada. Search for more papers by this author J.A. Martens J.A. Martens Department of Biochemistry, University of Western Ontario, London, Canada. Search for more papers by this author K.S. Hamilton K.S. Hamilton Department of Biochemistry, University of Western Ontario, London, Canada. Search for more papers by this author C.J. Brandl C.J. Brandl Department of Biochemistry, University of Western Ontario, London, Canada. Search for more papers by this author A.M. Furlanetto A.M. Furlanetto Department of Biochemistry, University of Western Ontario, London, Canada. Search for more papers by this author J.A. Martens J.A. Martens Department of Biochemistry, University of Western Ontario, London, Canada. Search for more papers by this author K.S. Hamilton K.S. Hamilton Department of Biochemistry, University of Western Ontario, London, Canada. Search for more papers by this author Author Information C.J. Brandl1, A.M. Furlanetto1, J.A. Martens1 and K.S. Hamilton1 1Department of Biochemistry, University of Western Ontario, London, Canada. The EMBO Journal (1993)12:5255-5265https://doi.org/10.1002/j.1460-2075.1993.tb06221.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The GAL1-10 genes of Saccharomyces cerevisiae are regulated by the interaction of cis- and trans-acting factors which facilitate activated transcription in galactose but not in glucose medium. By selecting mutations that allow expression of a defective gal1-10-his3 hybrid promoter, we have identified a novel gene, NGG1, which is required for glucose repression of the GAL10-related his3-G25 promoter. ngg1 was identified as a recessive null mutation that in the presence of a gal80 background resulted in a 300-fold relief of glucose repression for the his3-G25 promoter. This compared with a 20-fold and negligible relief of repression in gal80 and ngg1 strains, respectively. Deletion analysis of the his3-G25 promoter showed a correlation between the number of GAL4p binding sites and the relative level of NGG1p activity. Relief of glucose repression by NGG1 was dependent on the presence of GAL4, but was independent of the GAL4 promoter. In addition, NGG1p activity was seen for a promoter construct containing independent GAL4p binding sites. These results suggest that NGG1p acts to inhibit GAL4p function in glucose medium. We have cloned NGG1 by complementation and found that it contains an open reading frame of 2106 bp which could encode a protein with a molecular weight of 79,230. Previous ArticleNext Article Volume 12Issue 131 December 1993In this issue RelatedDetailsLoading ..." @default.
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• W958055355 date "1993-12-01" @default.
• W958055355 modified "2023-10-14" @default.
• W958055355 title "Characterization of NGG1, a novel yeast gene required for glucose repression of GAL4p-regulated transcription." @default.
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• W958055355 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06221.x" @default.
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