FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W958267958> ?p ?o ?g. }

• W958267958 endingPage "136" @default.
• W958267958 startingPage "125" @default.
• W958267958 abstract "The thioredoxin (Trx) system is one major redox system in mammalian cells. One of its component, Trx, is involved in redox homeostasis and many cellular biological processes through participating in disulfide reduction, S-nitrosylation/S-denitrosylation reactions and protein-protein interactions. In this study, we report the identification of a novel interaction between cytosolic/nuclear Trx1 and apoptosis inducing factor (AIF), and the redox sensitivity and biological significance of the Trx-AIF interaction was characterized. Cytosolic Trx1 but not mitochondrial Trx2 was observed to interact with AIF under physiological conditions and Trx1's active site cysteines were crucial for the interaction. Under oxidative stress conditions, Trx-AIF interaction was disrupted. When the treated cells were allowed to recover from oxidative stress by means of removal of the oxidants, interaction between Trx1 and AIF was re-established time-dependently, which underpins the biological relevance of a Trx-dependent redox regulation of AIF-mediated cell death. Indeed, in times of oxidative stress, nuclear translocation of AIF was found to occur concurrently with perturbations to the Trx-AIF interaction. Once localized in the nucleus, reduced Trx1 hindered the interaction between AIF and DNA, thereby bringing about an attenuation of AIF-mediated DNA damage. In conclusion, characterization of the Trx-AIF interaction has led to an understanding of the effect of reduced Trx1 on possibly regulating AIF-dependent cell death through impeding AIF-mediated DNA damage. Importantly, identification of the novel interaction between Trx1 and AIF has provided opportunities to design and develop therapeutically relevant strategies that either promote or prevent this protein-protein interaction for the treatment of different disease states." @default.
• W958267958 created "2016-06-24" @default.
• W958267958 creator A5035586555 @default.
• W958267958 creator A5047307349 @default.
• W958267958 creator A5054894084 @default.
• W958267958 creator A5064608982 @default.
• W958267958 creator A5068845562 @default.
• W958267958 creator A5073262855 @default.
• W958267958 creator A5073590397 @default.
• W958267958 creator A5076664348 @default.
• W958267958 creator A5079388173 @default.
• W958267958 creator A5079550858 @default.
• W958267958 date "2015-10-01" @default.
• W958267958 modified "2023-10-03" @default.
• W958267958 title "Thioredoxin-dependent regulation of AIF-mediated DNA damage" @default.
• W958267958 cites W154567916 @default.
• W958267958 cites W1943720579 @default.
• W958267958 cites W1965680695 @default.
• W958267958 cites W1969268163 @default.
• W958267958 cites W1975820695 @default.
• W958267958 cites W1976599392 @default.
• W958267958 cites W1977178308 @default.
• W958267958 cites W1989498664 @default.
• W958267958 cites W1990232129 @default.
• W958267958 cites W1999605572 @default.
• W958267958 cites W2006264758 @default.
• W958267958 cites W2011123535 @default.
• W958267958 cites W2011894191 @default.
• W958267958 cites W2013040616 @default.
• W958267958 cites W2014202579 @default.
• W958267958 cites W2014947131 @default.
• W958267958 cites W2025651276 @default.
• W958267958 cites W2028925334 @default.
• W958267958 cites W2030391962 @default.
• W958267958 cites W2031935406 @default.
• W958267958 cites W2032413974 @default.
• W958267958 cites W2032444047 @default.
• W958267958 cites W2034902084 @default.
• W958267958 cites W2035298043 @default.
• W958267958 cites W2045899523 @default.
• W958267958 cites W2048553024 @default.
• W958267958 cites W2050083026 @default.
• W958267958 cites W2058291762 @default.
• W958267958 cites W2058892278 @default.
• W958267958 cites W2059901120 @default.
• W958267958 cites W2060507522 @default.
• W958267958 cites W2062538700 @default.
• W958267958 cites W2068890239 @default.
• W958267958 cites W2074573663 @default.
• W958267958 cites W2077283763 @default.
• W958267958 cites W2084092576 @default.
• W958267958 cites W2085353670 @default.
• W958267958 cites W2085641738 @default.
• W958267958 cites W2086144679 @default.
• W958267958 cites W2093154548 @default.
• W958267958 cites W2097565612 @default.
• W958267958 cites W2108131089 @default.
• W958267958 cites W2110357545 @default.
• W958267958 cites W2117703821 @default.
• W958267958 cites W2125536365 @default.
• W958267958 cites W2132403739 @default.
• W958267958 cites W2137122673 @default.
• W958267958 cites W2141321721 @default.
• W958267958 cites W2147309521 @default.
• W958267958 cites W2149271491 @default.
• W958267958 cites W2149659371 @default.
• W958267958 cites W2154975058 @default.
• W958267958 cites W2155089409 @default.
• W958267958 cites W2158213789 @default.
• W958267958 cites W2159574886 @default.
• W958267958 cites W2159650080 @default.
• W958267958 cites W2165980159 @default.
• W958267958 cites W2180488799 @default.
• W958267958 doi "https://doi.org/10.1016/j.freeradbiomed.2015.06.029" @default.
• W958267958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26119781" @default.
• W958267958 hasPublicationYear "2015" @default.
• W958267958 type Work @default.
• W958267958 sameAs 958267958 @default.
• W958267958 citedByCount "36" @default.
• W958267958 countsByYear W9582679582016 @default.
• W958267958 countsByYear W9582679582017 @default.
• W958267958 countsByYear W9582679582018 @default.
• W958267958 countsByYear W9582679582019 @default.
• W958267958 countsByYear W9582679582020 @default.
• W958267958 countsByYear W9582679582021 @default.
• W958267958 countsByYear W9582679582022 @default.
• W958267958 countsByYear W9582679582023 @default.
• W958267958 crossrefType "journal-article" @default.
• W958267958 hasAuthorship W958267958A5035586555 @default.
• W958267958 hasAuthorship W958267958A5047307349 @default.
• W958267958 hasAuthorship W958267958A5054894084 @default.
• W958267958 hasAuthorship W958267958A5064608982 @default.
• W958267958 hasAuthorship W958267958A5068845562 @default.
• W958267958 hasAuthorship W958267958A5073262855 @default.
• W958267958 hasAuthorship W958267958A5073590397 @default.
• W958267958 hasAuthorship W958267958A5076664348 @default.
• W958267958 hasAuthorship W958267958A5079388173 @default.
• W958267958 hasAuthorship W958267958A5079550858 @default.

• next