FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W95827561> ?p ?o ?g. }

• W95827561 endingPage "138" @default.
• W95827561 startingPage "129" @default.
• W95827561 abstract "Allergic rhinitis is known to be one of the most common chronic diseases in the industrialized world. According to the concept that allergic rhinitis patients generally suffer from an immune deficit, in order to stimulate specifically or aspecifically their immune system, immunomodulating agents from various sources, such as synthetic compounds, tissue extracts or a mixture of bacterial extracts, have been used. The aim of the present trial is to evaluate the efficacy of the treatment with an immunostimulating vaccine consisting of a polyvalent mechanical bacterial lysate (PMBL) in the prophylaxis of allergic rhinitis and subsequently to analyze its in vivo effects on immune responses. 41 allergic rhinitis patients were enrolled: 26 patients were randomly assigned to the group for PMBL sublingual treatment and 15 others to the group for placebo treatment. For all 26 patients blood samples were drawn just before (T 0 ) and after 3 months of PMBL treatment (T 3 ) to evaluate plasma IgE levels (total and allergen-specific) and the cytokine production involved in the allergic response (IL-4, IFN-γ). The results of our study indicate that PMBL is effective in vivo in the reduction or in the elimination of the symptoms in rhinitis subjects during the treatment period in comparison to a non-immunostimulating treatment. A significant and clinically relevant improvement was found in 61.5%, a stationary clinical response was registered in 38.4% and no negative side effects associated with the medication or worsening were recorded. At the end of a 3-month follow up period the clinical picture remained the same as that observed at T 3 . PMBL treatment did not affect the serum IgE levels (either total or allergen-specific) and did not induce significant changes in IFN-γ concentration. In contrast, PMBL therapy may be accompanied, in some patients, by a potential immunomodulating activity by decreasing IL-4 cytokine expression." @default.
• W95827561 created "2016-06-24" @default.
• W95827561 creator A5002295981 @default.
• W95827561 creator A5012782136 @default.
• W95827561 creator A5015187471 @default.
• W95827561 creator A5020056645 @default.
• W95827561 creator A5039812301 @default.
• W95827561 creator A5043605894 @default.
• W95827561 creator A5053297187 @default.
• W95827561 creator A5064847334 @default.
• W95827561 creator A5069864433 @default.
• W95827561 creator A5076328498 @default.
• W95827561 creator A5079969740 @default.
• W95827561 creator A5091873435 @default.
• W95827561 date "2007-01-01" @default.
• W95827561 modified "2023-09-24" @default.
• W95827561 title "Improvement of Clinical Response in Allergic Rhinitis Patients Treated with an Oral Immunostimulating Bacterial Lysate: <i>In Vivo</i> Immunological Effects" @default.
• W95827561 cites W113041032 @default.
• W95827561 cites W1712893432 @default.
• W95827561 cites W1966578837 @default.
• W95827561 cites W1971773144 @default.
• W95827561 cites W1971871713 @default.
• W95827561 cites W1973755752 @default.
• W95827561 cites W1978318452 @default.
• W95827561 cites W1987680992 @default.
• W95827561 cites W1989465162 @default.
• W95827561 cites W1996404326 @default.
• W95827561 cites W2021399618 @default.
• W95827561 cites W2027964945 @default.
• W95827561 cites W2046531794 @default.
• W95827561 cites W2051584955 @default.
• W95827561 cites W2062202842 @default.
• W95827561 cites W2069462575 @default.
• W95827561 cites W2114626700 @default.
• W95827561 cites W2140435945 @default.
• W95827561 cites W2158232850 @default.
• W95827561 cites W2158860741 @default.
• W95827561 cites W2170409747 @default.
• W95827561 doi "https://doi.org/10.1177/039463200702000115" @default.
• W95827561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17346436" @default.
• W95827561 hasPublicationYear "2007" @default.
• W95827561 type Work @default.
• W95827561 sameAs 95827561 @default.
• W95827561 citedByCount "23" @default.
• W95827561 countsByYear W958275612013 @default.
• W95827561 countsByYear W958275612014 @default.
• W95827561 countsByYear W958275612018 @default.
• W95827561 countsByYear W958275612019 @default.
• W95827561 countsByYear W958275612020 @default.
• W95827561 countsByYear W958275612021 @default.
• W95827561 countsByYear W958275612022 @default.
• W95827561 countsByYear W958275612023 @default.
• W95827561 crossrefType "journal-article" @default.
• W95827561 hasAuthorship W95827561A5002295981 @default.
• W95827561 hasAuthorship W95827561A5012782136 @default.
• W95827561 hasAuthorship W95827561A5015187471 @default.
• W95827561 hasAuthorship W95827561A5020056645 @default.
• W95827561 hasAuthorship W95827561A5039812301 @default.
• W95827561 hasAuthorship W95827561A5043605894 @default.
• W95827561 hasAuthorship W95827561A5053297187 @default.
• W95827561 hasAuthorship W95827561A5064847334 @default.
• W95827561 hasAuthorship W95827561A5069864433 @default.
• W95827561 hasAuthorship W95827561A5076328498 @default.
• W95827561 hasAuthorship W95827561A5079969740 @default.
• W95827561 hasAuthorship W95827561A5091873435 @default.
• W95827561 hasBestOaLocation W958275611 @default.
• W95827561 hasConcept C126322002 @default.
• W95827561 hasConcept C141105273 @default.
• W95827561 hasConcept C142724271 @default.
• W95827561 hasConcept C150903083 @default.
• W95827561 hasConcept C159654299 @default.
• W95827561 hasConcept C203014093 @default.
• W95827561 hasConcept C204787440 @default.
• W95827561 hasConcept C207001950 @default.
• W95827561 hasConcept C207480886 @default.
• W95827561 hasConcept C27081682 @default.
• W95827561 hasConcept C2776953665 @default.
• W95827561 hasConcept C2780510475 @default.
• W95827561 hasConcept C535046627 @default.
• W95827561 hasConcept C71924100 @default.
• W95827561 hasConcept C86803240 @default.
• W95827561 hasConcept C8891405 @default.
• W95827561 hasConceptScore W95827561C126322002 @default.
• W95827561 hasConceptScore W95827561C141105273 @default.
• W95827561 hasConceptScore W95827561C142724271 @default.
• W95827561 hasConceptScore W95827561C150903083 @default.
• W95827561 hasConceptScore W95827561C159654299 @default.
• W95827561 hasConceptScore W95827561C203014093 @default.
• W95827561 hasConceptScore W95827561C204787440 @default.
• W95827561 hasConceptScore W95827561C207001950 @default.
• W95827561 hasConceptScore W95827561C207480886 @default.
• W95827561 hasConceptScore W95827561C27081682 @default.
• W95827561 hasConceptScore W95827561C2776953665 @default.
• W95827561 hasConceptScore W95827561C2780510475 @default.
• W95827561 hasConceptScore W95827561C535046627 @default.
• W95827561 hasConceptScore W95827561C71924100 @default.
• W95827561 hasConceptScore W95827561C86803240 @default.
• W95827561 hasConceptScore W95827561C8891405 @default.

• next