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- W958463507 abstract "Recent studies reveal that ascomycete fungi establish an endosymbiotic association with marine algae [1-4]. Akin to the endophytes of terrestrial plants in causing disease-free infections in their hosts, these fungi need to be studied with the same zeal as endophytes as they are a promising source of novel bioactive metabolites. The Fungal Endosymbionts of Macroalage (FEM) elaborate molecules exhibiting antitumour, antioxidant, anticancer, antimicrobial, antifungal, cytotoxic and other bioactivities [5-7]. An Aspergillus sp. harboured by a marine alga elaborates antibiotics effective against methicillin resistant bacteria [8]; FEM isolated from macroalgae of North Atlantic produce antibacterial and larvicidal metabolites [7]. A Fusarium endosymbiont of a marine alga off the coast of southern India formed antimalarial metabolites showing activity against blood stage Plasmodium falciparum [9]. The synthetic ability of FEM is further substantiated by Flewelling et al. [10] who showed that a Penicillium endosymbiont of Fucus spiralis produced epiepoformin, phlyllostine, patulin and cladosporin-a metabolite that has not been previously reported as a product of this genus. Although these few studies identify FEM as a promising source of novel metabolites of pharmaceutical and agricultural importance, a number of challenges confront us before their potential could be fully realized. We identify some roadblocks which need to be addressed." @default.
- W958463507 created "2016-06-24" @default.
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- W958463507 date "2014-01-01" @default.
- W958463507 modified "2023-10-18" @default.
- W958463507 title "Fungal Endosymbionts of Macroalgae: Need for Enquiries into Diversity and Technological Potential" @default.
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- W958463507 doi "https://doi.org/10.4172/2332-2632.1000119" @default.
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