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- W958471019 abstract "Thyroid hormone (TH) (thyroxine L-T4, triiodothyronine L-T3) has myriad effects on cellular growth, development, and metabolism. TH exerts its major effects at the genomic level, although there are examples of nongenomic action in the cytoplasm, plasma membrane, and mitochondrion. Early observations clearly established that TH could bind to nuclear sites and stimulate transcription and translation of new proteins (1–3). These important early observations and subsequent work from many laboratories led to a general model for genomic TH action. As seen in Fig. 1, circulating free TH enters the cell by passive diffusion and, in some tissues, is converted from T4 to the more biologically potent hormone T3. TH then enters the nucleus and binds to nuclear receptors (TRs) with high degrees of specificity and affinity. TRs have been shown to be intimately associated with chromatin, and ligand binding to TRs stimulates transcription of target genes and subsequent protein synthesis in a concentration- and timedependent manner. Although the critical role for TRs in TH action was established early, the identification and characterization of TRs remained elusive until just over a decade ago." @default.
- W958471019 created "2016-06-24" @default.
- W958471019 creator A5009257564 @default.
- W958471019 date "2000-01-01" @default.
- W958471019 modified "2023-09-27" @default.
- W958471019 title "Thyroid Hormone Receptors and Their Multiple Transcriptional Roles" @default.
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