FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W95854303> ?p ?o ?g. }

• W95854303 endingPage "66" @default.
• W95854303 startingPage "59" @default.
• W95854303 abstract "We describe here a genetic approach to the analysis of host cell functions involved in determining permissiveness to mouse hepatitis virus (MHV). Using the chemical mutagen, ethyl methane sulfonate (EMS), mouse fibroblast cell mutants were generated which were selected for resistance to cell-killing by MHV. These mutants were then screened for their susceptibility to MHV infection, ability to replicate MHV and relative sensitivity to MHV-induced cell fusion. In contrast to wild type L-2 cells which were acutely and terminally infected by MHV, all five mutants examined replicated MHV in a persistent manner. These mutants showed a reduced susceptibility to MHV infection and an increased resistance to MHV-induced cell fusion. Fusion resistance was specific to that mediated by the MHV E2 protein; mutant as well as wild type L-2 cells were equally sensitive to fusion by polyethylene glycol. The combined effect of reduced infectability and increased fusion resistance was to limit MHV infection to only a small percentage of the total cells in culture, thereby permitting survival of both virus and cells. The observed high rate of generation of the cell mutants suggests that the conversion of a fully MHV-susceptible cell to a semi-resistant one (capable of supporting a persistent infection) is a fairly common event, possibly involving a single mutation." @default.
• W95854303 created "2016-06-24" @default.
• W95854303 creator A5000412768 @default.
• W95854303 creator A5008704274 @default.
• W95854303 creator A5037938571 @default.
• W95854303 creator A5055855411 @default.
• W95854303 creator A5075787110 @default.
• W95854303 creator A5080573887 @default.
• W95854303 creator A5087844269 @default.
• W95854303 date "1990-01-01" @default.
• W95854303 modified "2023-09-25" @default.
• W95854303 title "Mouse Fibroblast Mutants Selected for Survival Against Mouse Hepatitis Virus Infection Show Increased Resistance to Infection and Virus-Induced Cell Fusion" @default.
• W95854303 cites W1528736712 @default.
• W95854303 cites W1532900807 @default.
• W95854303 cites W1542986779 @default.
• W95854303 cites W1775495809 @default.
• W95854303 cites W1777825410 @default.
• W95854303 cites W1992089677 @default.
• W95854303 cites W2000912276 @default.
• W95854303 cites W2023196220 @default.
• W95854303 cites W2023724636 @default.
• W95854303 cites W2036928923 @default.
• W95854303 cites W2070691419 @default.
• W95854303 cites W2072913773 @default.
• W95854303 cites W2096504789 @default.
• W95854303 cites W2131666887 @default.
• W95854303 cites W2141202074 @default.
• W95854303 cites W2141306074 @default.
• W95854303 cites W2160043445 @default.
• W95854303 cites W2164925836 @default.
• W95854303 cites W2410249347 @default.
• W95854303 cites W4255236900 @default.
• W95854303 cites W5047070 @default.
• W95854303 doi "https://doi.org/10.1007/978-1-4684-5823-7_9" @default.
• W95854303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1966453" @default.
• W95854303 hasPublicationYear "1990" @default.
• W95854303 type Work @default.
• W95854303 sameAs 95854303 @default.
• W95854303 citedByCount "2" @default.
• W95854303 countsByYear W958543032020 @default.
• W95854303 crossrefType "book-chapter" @default.
• W95854303 hasAuthorship W95854303A5000412768 @default.
• W95854303 hasAuthorship W95854303A5008704274 @default.
• W95854303 hasAuthorship W95854303A5037938571 @default.
• W95854303 hasAuthorship W95854303A5055855411 @default.
• W95854303 hasAuthorship W95854303A5075787110 @default.
• W95854303 hasAuthorship W95854303A5080573887 @default.
• W95854303 hasAuthorship W95854303A5087844269 @default.
• W95854303 hasConcept C104317684 @default.
• W95854303 hasConcept C140704245 @default.
• W95854303 hasConcept C142724271 @default.
• W95854303 hasConcept C143065580 @default.
• W95854303 hasConcept C1491633281 @default.
• W95854303 hasConcept C153911025 @default.
• W95854303 hasConcept C159047783 @default.
• W95854303 hasConcept C2522874641 @default.
• W95854303 hasConcept C2777890099 @default.
• W95854303 hasConcept C2779134260 @default.
• W95854303 hasConcept C2779567548 @default.
• W95854303 hasConcept C2780381497 @default.
• W95854303 hasConcept C3008058167 @default.
• W95854303 hasConcept C3018250846 @default.
• W95854303 hasConcept C524204448 @default.
• W95854303 hasConcept C54355233 @default.
• W95854303 hasConcept C71924100 @default.
• W95854303 hasConcept C81885089 @default.
• W95854303 hasConcept C86803240 @default.
• W95854303 hasConcept C89423630 @default.
• W95854303 hasConcept C92488253 @default.
• W95854303 hasConceptScore W95854303C104317684 @default.
• W95854303 hasConceptScore W95854303C140704245 @default.
• W95854303 hasConceptScore W95854303C142724271 @default.
• W95854303 hasConceptScore W95854303C143065580 @default.
• W95854303 hasConceptScore W95854303C1491633281 @default.
• W95854303 hasConceptScore W95854303C153911025 @default.
• W95854303 hasConceptScore W95854303C159047783 @default.
• W95854303 hasConceptScore W95854303C2522874641 @default.
• W95854303 hasConceptScore W95854303C2777890099 @default.
• W95854303 hasConceptScore W95854303C2779134260 @default.
• W95854303 hasConceptScore W95854303C2779567548 @default.
• W95854303 hasConceptScore W95854303C2780381497 @default.
• W95854303 hasConceptScore W95854303C3008058167 @default.
• W95854303 hasConceptScore W95854303C3018250846 @default.
• W95854303 hasConceptScore W95854303C524204448 @default.
• W95854303 hasConceptScore W95854303C54355233 @default.
• W95854303 hasConceptScore W95854303C71924100 @default.
• W95854303 hasConceptScore W95854303C81885089 @default.
• W95854303 hasConceptScore W95854303C86803240 @default.
• W95854303 hasConceptScore W95854303C89423630 @default.
• W95854303 hasConceptScore W95854303C92488253 @default.
• W95854303 hasLocation W958543031 @default.
• W95854303 hasLocation W958543032 @default.
• W95854303 hasOpenAccess W95854303 @default.
• W95854303 hasPrimaryLocation W958543031 @default.
• W95854303 hasRelatedWork W1487857142 @default.
• W95854303 hasRelatedWork W1973058328 @default.
• W95854303 hasRelatedWork W1991126365 @default.
• W95854303 hasRelatedWork W1997242574 @default.

• next