Matches in SemOpenAlex for { <https://semopenalex.org/work/W95859248> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W95859248 abstract "Background: The recent discontinuation of the AIM-HIGH study suggests that even HDL and TG levels do not adequately predict cardiovascular disease outcome. Angiogenesis, an integrated intramural biomarker of plaque progression, has been quantitatively and rapidly used for T1-weighted MR imaging with targeted gadolinium nanoparticles (PFC NPs), but new agents with even lower lanthanide levels are desired. Objective: We hypothesized that targeted manganese-oleate core NCs that present 30-fold less Gd than PFC NPs could provide strong, T1-weighted MR imaging of neovascular α v β 3 -integrin expression in vivo. Methods and Results: Vascularly-constrained (D av =140 nm, ζ=-13mV) nanocolloids (NC) of Mn oleate (20% v/v) were synthesized using only 1.25mole% of Gd as (versus 30 mole% for PFC NPs), 0.25 mole% of a quinolone-derived α v β 3 -integrin antagonist, and 98.5 mole% lecithin. Cholesterol fed New Zealand White rabbits (n=8/group) received α v β 3 -Mn(Gd)-NC or nontargeted Mn(Gd)-NC i.v. (1ml/kg); 8 rabbits on normal chow received α v β 3 -Mn(Gd)-NC. Dynamic MR imaging (3.0T) of the descending thoracic aorta wall revealed a marked signal enhancement (47±5%) at 2h. In comparison, the nontargeted-MnGd-NC had lower (20±5%) signal enhancement than targeted NPs (p v β 3 -MnGd NP had the lowest signal increase, 12±3%, which did not differ from the nontargeted treatment. Histology corroborated the prominent, neointimal proliferation among cholesterol-fed, and homing specificity. Conclusions: Angiogenesis imaging offers a direct intramural measure of atherosclerotic disease progression and α v β 3 -Mn(Gd)-NC provides a sensitive MR molecular imaging approach with gadolinium decreased to 300-fold less than clinical single dose Gd-DTPA." @default.
- W95859248 created "2016-06-24" @default.
- W95859248 creator A5010692274 @default.
- W95859248 creator A5025202937 @default.
- W95859248 creator A5042700347 @default.
- W95859248 creator A5046404222 @default.
- W95859248 creator A5055819205 @default.
- W95859248 creator A5056477853 @default.
- W95859248 creator A5071887150 @default.
- W95859248 creator A5074873780 @default.
- W95859248 date "2011-11-22" @default.
- W95859248 modified "2023-09-23" @default.
- W95859248 title "Abstract 17074: T1-Weighted MR Imaging of Aortic Angiogenesis in Rabbits with an Ultralow New Low Gadolinium" @default.
- W95859248 hasPublicationYear "2011" @default.
- W95859248 type Work @default.
- W95859248 sameAs 95859248 @default.
- W95859248 citedByCount "0" @default.
- W95859248 crossrefType "journal-article" @default.
- W95859248 hasAuthorship W95859248A5010692274 @default.
- W95859248 hasAuthorship W95859248A5025202937 @default.
- W95859248 hasAuthorship W95859248A5042700347 @default.
- W95859248 hasAuthorship W95859248A5046404222 @default.
- W95859248 hasAuthorship W95859248A5055819205 @default.
- W95859248 hasAuthorship W95859248A5056477853 @default.
- W95859248 hasAuthorship W95859248A5071887150 @default.
- W95859248 hasAuthorship W95859248A5074873780 @default.
- W95859248 hasConcept C142724271 @default.
- W95859248 hasConcept C150903083 @default.
- W95859248 hasConcept C178790620 @default.
- W95859248 hasConcept C185592680 @default.
- W95859248 hasConcept C207001950 @default.
- W95859248 hasConcept C26291073 @default.
- W95859248 hasConcept C2778271429 @default.
- W95859248 hasConcept C2780394083 @default.
- W95859248 hasConcept C2781197716 @default.
- W95859248 hasConcept C2989005 @default.
- W95859248 hasConcept C502942594 @default.
- W95859248 hasConcept C55493867 @default.
- W95859248 hasConcept C557651011 @default.
- W95859248 hasConcept C71924100 @default.
- W95859248 hasConcept C86803240 @default.
- W95859248 hasConceptScore W95859248C142724271 @default.
- W95859248 hasConceptScore W95859248C150903083 @default.
- W95859248 hasConceptScore W95859248C178790620 @default.
- W95859248 hasConceptScore W95859248C185592680 @default.
- W95859248 hasConceptScore W95859248C207001950 @default.
- W95859248 hasConceptScore W95859248C26291073 @default.
- W95859248 hasConceptScore W95859248C2778271429 @default.
- W95859248 hasConceptScore W95859248C2780394083 @default.
- W95859248 hasConceptScore W95859248C2781197716 @default.
- W95859248 hasConceptScore W95859248C2989005 @default.
- W95859248 hasConceptScore W95859248C502942594 @default.
- W95859248 hasConceptScore W95859248C55493867 @default.
- W95859248 hasConceptScore W95859248C557651011 @default.
- W95859248 hasConceptScore W95859248C71924100 @default.
- W95859248 hasConceptScore W95859248C86803240 @default.
- W95859248 hasLocation W958592481 @default.
- W95859248 hasOpenAccess W95859248 @default.
- W95859248 hasPrimaryLocation W958592481 @default.
- W95859248 hasRelatedWork W1603033543 @default.
- W95859248 hasRelatedWork W1973095729 @default.
- W95859248 hasRelatedWork W1976527688 @default.
- W95859248 hasRelatedWork W1985445109 @default.
- W95859248 hasRelatedWork W1998129712 @default.
- W95859248 hasRelatedWork W2022477370 @default.
- W95859248 hasRelatedWork W2053474834 @default.
- W95859248 hasRelatedWork W2084585439 @default.
- W95859248 hasRelatedWork W2127248822 @default.
- W95859248 hasRelatedWork W2133428169 @default.
- W95859248 hasRelatedWork W2162597084 @default.
- W95859248 hasRelatedWork W2186572244 @default.
- W95859248 hasRelatedWork W2355829818 @default.
- W95859248 hasRelatedWork W2355989326 @default.
- W95859248 hasRelatedWork W2386364175 @default.
- W95859248 hasRelatedWork W2390739142 @default.
- W95859248 hasRelatedWork W2470424349 @default.
- W95859248 hasRelatedWork W2589061450 @default.
- W95859248 hasRelatedWork W3029654126 @default.
- W95859248 hasRelatedWork W3139252006 @default.
- W95859248 hasVolume "124" @default.
- W95859248 isParatext "false" @default.
- W95859248 isRetracted "false" @default.
- W95859248 magId "95859248" @default.
- W95859248 workType "article" @default.