FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W95890646> ?p ?o ?g. }

• W95890646 abstract "Cell-based therapies are a potential therapeutic alternative for the treatment of coronary artery disease (CAD). However, transplanted cells undergo significant death in the living subject. Hypoxic preconditioning (HPC) is a potential intervention to increase transplanted cell survival. However, the biological mechanisms of this benefit remain unclear. We hypothesize that the beneficial effect of HPC on stem cell survival is in part due to preservation of oxidant status, an effect that will be monitored using state-of-the-art molecular imaging.H9c2 rat cardiomyoblasts expressing the construct CMV-firefly luciferase (h9c2-fluc), with and without HPC, were exposed to hypoxia, and oxidative stress and cell survival were measured. Subsequently, H9c2-fluc cells, with and without HPC, were injected into the myocardium of rats and cell survival was monitored daily with Bioluminescence (BLI) using a CCD camera.Compared to controls, cells exposed to hypoxia had increased amount of reactive oxygen species (ROS, control: 14.1±0.9 vs. hypoxia: 19.5 ± 2.0 RFU/µg protein, P=0.02) and decreased cell survival (control: 0.29 ± 0.005 vs. hypoxia: 0.24 ± 0.005 OD, P<0.001). HPC treatment decreased the amount of hypoxia-induced ROS (HPC: 11.5 ± 0.7RFU/µg protein, P=0.002 vs. hypoxia and P=0.11 vs. control), associated with improved survival (HPC: 0.27 ± 0.004OD/µg protein, P=0.002 vs. hypoxia and P=0.005 vs. control). Most importantly, compared to un-conditioned cells, HPC-cells had increased cell survival after transplantation to the myocardium (C: 34.7 ± 6.7% vs. HPC: 83.4 ± 17.5% at day 5 compared to day 1, P=0.01).The beneficial effect of HPC is in part due to preservation of oxidant status. Molecular imaging can assess changes in cell survival in the living subject and has the potential to be applied clinically." @default.
• W95890646 created "2016-06-24" @default.
• W95890646 creator A5013250821 @default.
• W95890646 creator A5029129626 @default.
• W95890646 creator A5037694204 @default.
• W95890646 creator A5064946150 @default.
• W95890646 creator A5068152117 @default.
• W95890646 date "2011-08-01" @default.
• W95890646 modified "2023-09-29" @default.
• W95890646 title "Role of oxidative stress in hypoxia preconditioning of cells transplanted to the myocardium: a molecular imaging study." @default.
• W95890646 cites W1631250427 @default.
• W95890646 cites W1974962865 @default.
• W95890646 cites W1990721782 @default.
• W95890646 cites W1993952575 @default.
• W95890646 cites W2004969849 @default.
• W95890646 cites W2025280920 @default.
• W95890646 cites W2044815096 @default.
• W95890646 cites W2048568422 @default.
• W95890646 cites W2052914652 @default.
• W95890646 cites W2061220009 @default.
• W95890646 cites W2068440755 @default.
• W95890646 cites W2082676754 @default.
• W95890646 cites W2086136442 @default.
• W95890646 cites W2098276850 @default.
• W95890646 cites W2098849525 @default.
• W95890646 cites W2114918609 @default.
• W95890646 cites W2121968259 @default.
• W95890646 cites W2123193350 @default.
• W95890646 cites W2132122551 @default.
• W95890646 cites W2167946663 @default.
• W95890646 cites W2168961368 @default.
• W95890646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3146041" @default.
• W95890646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21792164" @default.
• W95890646 hasPublicationYear "2011" @default.
• W95890646 type Work @default.
• W95890646 sameAs 95890646 @default.
• W95890646 citedByCount "4" @default.
• W95890646 countsByYear W958906462012 @default.
• W95890646 countsByYear W958906462016 @default.
• W95890646 countsByYear W958906462017 @default.
• W95890646 countsByYear W958906462018 @default.
• W95890646 crossrefType "journal-article" @default.
• W95890646 hasAuthorship W95890646A5013250821 @default.
• W95890646 hasAuthorship W95890646A5029129626 @default.
• W95890646 hasAuthorship W95890646A5037694204 @default.
• W95890646 hasAuthorship W95890646A5064946150 @default.
• W95890646 hasAuthorship W95890646A5068152117 @default.
• W95890646 hasConcept C111335760 @default.
• W95890646 hasConcept C126322002 @default.
• W95890646 hasConcept C1491633281 @default.
• W95890646 hasConcept C161997846 @default.
• W95890646 hasConcept C164705383 @default.
• W95890646 hasConcept C178790620 @default.
• W95890646 hasConcept C185592680 @default.
• W95890646 hasConcept C190283241 @default.
• W95890646 hasConcept C2776151105 @default.
• W95890646 hasConcept C2778213512 @default.
• W95890646 hasConcept C2779389132 @default.
• W95890646 hasConcept C28328180 @default.
• W95890646 hasConcept C2911091166 @default.
• W95890646 hasConcept C3019137385 @default.
• W95890646 hasConcept C31573885 @default.
• W95890646 hasConcept C502942594 @default.
• W95890646 hasConcept C540031477 @default.
• W95890646 hasConcept C54009773 @default.
• W95890646 hasConcept C54355233 @default.
• W95890646 hasConcept C55493867 @default.
• W95890646 hasConcept C71924100 @default.
• W95890646 hasConcept C7836513 @default.
• W95890646 hasConcept C81885089 @default.
• W95890646 hasConcept C86803240 @default.
• W95890646 hasConcept C95444343 @default.
• W95890646 hasConceptScore W95890646C111335760 @default.
• W95890646 hasConceptScore W95890646C126322002 @default.
• W95890646 hasConceptScore W95890646C1491633281 @default.
• W95890646 hasConceptScore W95890646C161997846 @default.
• W95890646 hasConceptScore W95890646C164705383 @default.
• W95890646 hasConceptScore W95890646C178790620 @default.
• W95890646 hasConceptScore W95890646C185592680 @default.
• W95890646 hasConceptScore W95890646C190283241 @default.
• W95890646 hasConceptScore W95890646C2776151105 @default.
• W95890646 hasConceptScore W95890646C2778213512 @default.
• W95890646 hasConceptScore W95890646C2779389132 @default.
• W95890646 hasConceptScore W95890646C28328180 @default.
• W95890646 hasConceptScore W95890646C2911091166 @default.
• W95890646 hasConceptScore W95890646C3019137385 @default.
• W95890646 hasConceptScore W95890646C31573885 @default.
• W95890646 hasConceptScore W95890646C502942594 @default.
• W95890646 hasConceptScore W95890646C540031477 @default.
• W95890646 hasConceptScore W95890646C54009773 @default.
• W95890646 hasConceptScore W95890646C54355233 @default.
• W95890646 hasConceptScore W95890646C55493867 @default.
• W95890646 hasConceptScore W95890646C71924100 @default.
• W95890646 hasConceptScore W95890646C7836513 @default.
• W95890646 hasConceptScore W95890646C81885089 @default.
• W95890646 hasConceptScore W95890646C86803240 @default.
• W95890646 hasConceptScore W95890646C95444343 @default.
• W95890646 hasLocation W958906461 @default.
• W95890646 hasOpenAccess W95890646 @default.
• W95890646 hasPrimaryLocation W958906461 @default.

• next