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• W959091834 abstract "This chapter describes pharmacology of interleukin-1 (IL-1) actions in the brain. In most cases, mimic the host defense responses to infection, injury, and inflammation. Therefore, IL-1 appears to act as an important factor in the multiple connections among immune, nervous, and endocrine systems, which may be of direct clinical relevance. As yet, direct evidence for a role of endogenous IL-1 in host defense responses exists only for a few parameters, but the increasing availability of neutralizing rodent IL-1 antibodies and IL-1 receptor antagonist will probably signal a rapid expansion of this field and of the understanding of the biological relevance of IL-1. The diverse actions of IL-1 on the brain apparently involve multiple receptor subtypes, mechanisms, and endogenous inhibitors. These findings may be beneficial in the ongoing search for selective pharmacological modifiers of IL-1 synthesis and action, which could prove to be valuable tools in the treatment of various aspects of systemic disease and specific neurological conditions, such as cerebral ischemia, brain injury, CNS infections, and Alzheimer's disease." @default.
• W959091834 created "2016-06-24" @default.
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• W959091834 creator A5010610547 @default.
• W959091834 date "1994-01-01" @default.
• W959091834 modified "2023-10-18" @default.
• W959091834 title "Pharmacology of Interleukin-1 Actions in the Brain" @default.
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• W959091834 doi "https://doi.org/10.1016/s1054-3589(08)60428-7" @default.
• W959091834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8204500" @default.
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