Matches in SemOpenAlex for { <https://semopenalex.org/work/W95912110> ?p ?o ?g. }
- W95912110 endingPage "12" @default.
- W95912110 startingPage "207" @default.
- W95912110 abstract "We have studied the effect of IgA- and IgG-containing immune complexes on the production of complement proteins C3, factor B and C2 by human monocyte-derived macrophages, using biosynthetic labelling, immunoprecipitation, sodium dodecyl sulphate-polyacrylamide gel (SDS-PAGE) and autoradiography. There was a consistent increase in C3 production and secretion with both IgA and IgG immune complexes. This increase appeared after a 24-hr incubation period of the macrophages in the presence of immune complexes. No change in the biosynthesis of factor B and C2 proteins was observed in these experiments. Concomitant with the enhanced C3 biosynthesis, the immune complexes caused an increase in macrophage tumour necrosis factor (TNF) production; 310 + 24 U/ml/5 x 10(5) cells and 430 + 51 U/ml/5 x 10(5) cells for IgA and IgG immune complexes, respectively, versus 12 + 8 U/ml/5 x 10(5) cells in the control cells. The presence of prednisolone (2 x 10(-5) M) or dexamethasone (1 x 10(-7) M) inhibited the immune complex-induced TNF production, but had no effect on C3-increased synthesis, suggesting that the effect of immune complexes was not mediated by endogenous TNF production. These findings may be relevant to the local inflammatory response in IgA immune complex-mediated diseases, including IgA nephropathy." @default.
- W95912110 created "2016-06-24" @default.
- W95912110 creator A5009219744 @default.
- W95912110 creator A5025119371 @default.
- W95912110 creator A5073025839 @default.
- W95912110 creator A5080627606 @default.
- W95912110 date "1995-02-01" @default.
- W95912110 modified "2023-10-05" @default.
- W95912110 title "IgA and IgG immune complexes increase human macrophage C3 biosynthesis." @default.
- W95912110 cites W115085921 @default.
- W95912110 cites W142717363 @default.
- W95912110 cites W1484051880 @default.
- W95912110 cites W1513641086 @default.
- W95912110 cites W1521161025 @default.
- W95912110 cites W1558633308 @default.
- W95912110 cites W1595865874 @default.
- W95912110 cites W1608490603 @default.
- W95912110 cites W1664497787 @default.
- W95912110 cites W1848552725 @default.
- W95912110 cites W1931314445 @default.
- W95912110 cites W1934893658 @default.
- W95912110 cites W1942672363 @default.
- W95912110 cites W1971135092 @default.
- W95912110 cites W1981384391 @default.
- W95912110 cites W1986992784 @default.
- W95912110 cites W1987741250 @default.
- W95912110 cites W1999659638 @default.
- W95912110 cites W2003651638 @default.
- W95912110 cites W2003844263 @default.
- W95912110 cites W2013640301 @default.
- W95912110 cites W2014964931 @default.
- W95912110 cites W2016902102 @default.
- W95912110 cites W2022433281 @default.
- W95912110 cites W2032310876 @default.
- W95912110 cites W2047047291 @default.
- W95912110 cites W2050337792 @default.
- W95912110 cites W2057108750 @default.
- W95912110 cites W2075767924 @default.
- W95912110 cites W2076545205 @default.
- W95912110 cites W2079945014 @default.
- W95912110 cites W2125247444 @default.
- W95912110 cites W2179044022 @default.
- W95912110 cites W2407730053 @default.
- W95912110 cites W2410782647 @default.
- W95912110 cites W2414592894 @default.
- W95912110 cites W33014942 @default.
- W95912110 cites W349572682 @default.
- W95912110 cites W62771806 @default.
- W95912110 cites W98763143 @default.
- W95912110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1415113" @default.
- W95912110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7750996" @default.
- W95912110 hasPublicationYear "1995" @default.
- W95912110 type Work @default.
- W95912110 sameAs 95912110 @default.
- W95912110 citedByCount "7" @default.
- W95912110 countsByYear W959121102017 @default.
- W95912110 countsByYear W959121102022 @default.
- W95912110 countsByYear W959121102023 @default.
- W95912110 crossrefType "journal-article" @default.
- W95912110 hasAuthorship W95912110A5009219744 @default.
- W95912110 hasAuthorship W95912110A5025119371 @default.
- W95912110 hasAuthorship W95912110A5073025839 @default.
- W95912110 hasAuthorship W95912110A5080627606 @default.
- W95912110 hasConcept C153911025 @default.
- W95912110 hasConcept C159654299 @default.
- W95912110 hasConcept C17991360 @default.
- W95912110 hasConcept C185592680 @default.
- W95912110 hasConcept C202751555 @default.
- W95912110 hasConcept C203014093 @default.
- W95912110 hasConcept C2779102806 @default.
- W95912110 hasConcept C2779244956 @default.
- W95912110 hasConcept C2780898057 @default.
- W95912110 hasConcept C2781184567 @default.
- W95912110 hasConcept C49382859 @default.
- W95912110 hasConcept C55493867 @default.
- W95912110 hasConcept C71829478 @default.
- W95912110 hasConcept C86803240 @default.
- W95912110 hasConcept C8891405 @default.
- W95912110 hasConceptScore W95912110C153911025 @default.
- W95912110 hasConceptScore W95912110C159654299 @default.
- W95912110 hasConceptScore W95912110C17991360 @default.
- W95912110 hasConceptScore W95912110C185592680 @default.
- W95912110 hasConceptScore W95912110C202751555 @default.
- W95912110 hasConceptScore W95912110C203014093 @default.
- W95912110 hasConceptScore W95912110C2779102806 @default.
- W95912110 hasConceptScore W95912110C2779244956 @default.
- W95912110 hasConceptScore W95912110C2780898057 @default.
- W95912110 hasConceptScore W95912110C2781184567 @default.
- W95912110 hasConceptScore W95912110C49382859 @default.
- W95912110 hasConceptScore W95912110C55493867 @default.
- W95912110 hasConceptScore W95912110C71829478 @default.
- W95912110 hasConceptScore W95912110C86803240 @default.
- W95912110 hasConceptScore W95912110C8891405 @default.
- W95912110 hasIssue "2" @default.
- W95912110 hasLocation W959121101 @default.
- W95912110 hasOpenAccess W95912110 @default.
- W95912110 hasPrimaryLocation W959121101 @default.
- W95912110 hasRelatedWork W2075619296 @default.