Matches in SemOpenAlex for { <https://semopenalex.org/work/W959544653> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W959544653 endingPage "104" @default.
- W959544653 startingPage "99" @default.
- W959544653 abstract "Only β-NGF, the subunit of the 7S NGF complex, exhibits NGF activity, but the function ofthe zinc ion in native β-NGF has received little attention. Flameless atomic absorption spectroscopy (FAAS)measurements reveal that native β-NGF contains Zn(Ⅱ) with a Zn(Ⅱ)/β-NGF stoichiometry of 1 : 14.6.The presence of Zn(Ⅱ) in the native molecule results in significant changes of the secondary structure andlocal tertiary structure around Trp(s) with respect to those of apo β-NGF, as suggested by spectra offluorescence and circular dichrosim. Stopped-flow studies show that there are at least two steps during theinteraction of Zn(Ⅱ) with the apo form. In comparison with its apo form, the native β-NGF shows a higherability to trigger the proliferation of TF1 cells and mediate the survival of PC 12. Thus it is most likely that thestructural changes caused by the presence of Zn(II) directly lead to the increase in the biological activity of β-NGE All results indicate that Zn(Ⅱ) in native β-NGF plays an important role in the structure and thebiological activity of the protein." @default.
- W959544653 created "2016-06-24" @default.
- W959544653 creator A5016917391 @default.
- W959544653 creator A5074674541 @default.
- W959544653 creator A5076565213 @default.
- W959544653 creator A5078985361 @default.
- W959544653 date "2004-01-01" @default.
- W959544653 modified "2023-09-24" @default.
- W959544653 title "Effect of Zn（II） on the Structure and Biological Activity of Natural β-NGF" @default.
- W959544653 hasPublicationYear "2004" @default.
- W959544653 type Work @default.
- W959544653 sameAs 959544653 @default.
- W959544653 citedByCount "0" @default.
- W959544653 crossrefType "journal-article" @default.
- W959544653 hasAuthorship W959544653A5016917391 @default.
- W959544653 hasAuthorship W959544653A5074674541 @default.
- W959544653 hasAuthorship W959544653A5076565213 @default.
- W959544653 hasAuthorship W959544653A5078985361 @default.
- W959544653 hasConcept C104292427 @default.
- W959544653 hasConcept C104317684 @default.
- W959544653 hasConcept C116073593 @default.
- W959544653 hasConcept C12554922 @default.
- W959544653 hasConcept C170493617 @default.
- W959544653 hasConcept C178790620 @default.
- W959544653 hasConcept C185592680 @default.
- W959544653 hasConcept C202751555 @default.
- W959544653 hasConcept C2778423431 @default.
- W959544653 hasConcept C535196362 @default.
- W959544653 hasConcept C55493867 @default.
- W959544653 hasConcept C8010536 @default.
- W959544653 hasConcept C86803240 @default.
- W959544653 hasConceptScore W959544653C104292427 @default.
- W959544653 hasConceptScore W959544653C104317684 @default.
- W959544653 hasConceptScore W959544653C116073593 @default.
- W959544653 hasConceptScore W959544653C12554922 @default.
- W959544653 hasConceptScore W959544653C170493617 @default.
- W959544653 hasConceptScore W959544653C178790620 @default.
- W959544653 hasConceptScore W959544653C185592680 @default.
- W959544653 hasConceptScore W959544653C202751555 @default.
- W959544653 hasConceptScore W959544653C2778423431 @default.
- W959544653 hasConceptScore W959544653C535196362 @default.
- W959544653 hasConceptScore W959544653C55493867 @default.
- W959544653 hasConceptScore W959544653C8010536 @default.
- W959544653 hasConceptScore W959544653C86803240 @default.
- W959544653 hasIssue "2" @default.
- W959544653 hasLocation W9595446531 @default.
- W959544653 hasOpenAccess W959544653 @default.
- W959544653 hasPrimaryLocation W9595446531 @default.
- W959544653 hasRelatedWork W1506971774 @default.
- W959544653 hasRelatedWork W1535873009 @default.
- W959544653 hasRelatedWork W1970712942 @default.
- W959544653 hasRelatedWork W1979213522 @default.
- W959544653 hasRelatedWork W1981821934 @default.
- W959544653 hasRelatedWork W1989644658 @default.
- W959544653 hasRelatedWork W1991120755 @default.
- W959544653 hasRelatedWork W2006013855 @default.
- W959544653 hasRelatedWork W2009620135 @default.
- W959544653 hasRelatedWork W2022024815 @default.
- W959544653 hasRelatedWork W2040017395 @default.
- W959544653 hasRelatedWork W2057659564 @default.
- W959544653 hasRelatedWork W2073368143 @default.
- W959544653 hasRelatedWork W2097544903 @default.
- W959544653 hasRelatedWork W2396785050 @default.
- W959544653 hasRelatedWork W293299936 @default.
- W959544653 hasVolume "36" @default.
- W959544653 isParatext "false" @default.
- W959544653 isRetracted "false" @default.
- W959544653 magId "959544653" @default.
- W959544653 workType "article" @default.