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• W959791702 startingPage "811" @default.
• W959791702 abstract "Overconsumption of dietary fat is increasingly linked with motivational and emotional impairments. Human and animal studies demonstrate associations between obesity and blunted reward function at the behavioral and neural level, but it is unclear to what degree such changes are a consequence of an obese state and whether they are contingent on dietary lipid class. We sought to determine the impact of prolonged ad libitum intake of diets rich in saturated or monounsaturated fat, separate from metabolic signals associated with increased adiposity, on dopamine (DA)-dependent behaviors and to identify pertinent signaling changes in the nucleus accumbens (NAc). Male rats fed a saturated (palm oil), but not an isocaloric monounsaturated (olive oil), high-fat diet exhibited decreased sensitivity to the rewarding (place preference) and locomotor-sensitizing effects of amphetamine as compared with low-fat diet controls. Blunted amphetamine action by saturated high-fat feeding was entirely independent of caloric intake, weight gain, and plasma levels of leptin, insulin, and glucose and was accompanied by biochemical and behavioral evidence of reduced D1R signaling in the NAc. Saturated high-fat feeding was also tied to protein markers of increased AMPA receptor-mediated plasticity and decreased DA transporter expression in the NAc but not to alterations in DA turnover and biosynthesis. Collectively, the results suggest that intake of saturated lipids can suppress DA signaling apart from increases in body weight and adiposity-related signals known to affect mesolimbic DA function, in part by diminishing D1 receptor signaling, and that equivalent intake of monounsaturated dietary fat protects against such changes." @default.
• W959791702 created "2016-06-24" @default.
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• W959791702 creator A5043200324 @default.
• W959791702 creator A5053617026 @default.
• W959791702 creator A5060402478 @default.
• W959791702 date "2015-07-14" @default.
• W959791702 modified "2023-10-17" @default.
• W959791702 title "Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids" @default.
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• W959791702 doi "https://doi.org/10.1038/npp.2015.207" @default.
• W959791702 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4707827" @default.
• W959791702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26171719" @default.
• W959791702 hasPublicationYear "2015" @default.
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