FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W959897010> ?p ?o ?g. }

• W959897010 abstract "In vertebrates the Major Histocompatibility Complex (MHC) plays a central role in the specific immune defence against various pathogens. Compared with other coding genes the MHC genes exhibit an extremely high level of polymorphism that is maintained by balancing selection. The importance in the immune defence and the polymorphism make these genes interesting to study from an ecological and evolutionary perspective in populations subject to natural selection. In my thesis I have studied MHC in a population of wild songbirds, great reed warblers Acrocephalus arundinaceus. Firstly, I characterized parts of the MHC class I and II genes and I focused especially on transcribed genes since these are likely to be under selection. Then I developed a PCR-based screening method for investigating the MHC class I polymorphism in our study population. In the great reed warbler genome there was a large number of MHC class I and II genes and there was also evidence of balancing selection in these genes. There was a surprisingly high level of variation in the MHC genes in the great reed warblers within the study population considering the limited variation that have been detected using neutral markers. Secondly, I searched for evidence of selection on the MHC genes and for associations between life-history data and MHC genes. I found evidence that there is selection on the MHC class I alleles in great reed warblers. Avian malaria could be one such selective force since great reed warblers that had a large number of MHC alleles (heterozygous individuals) survived an infection with avian malaria (GRW2) more often than individuals with fewer MHC alleles. Hence, a large number of MHC alleles seem critical for survival. However, we did not find that MHC-compatibility is involved in female mate choice in the great reed warblers, as has been found in humans and mice, despite the fact that more MHC heterozygous great reed warbler siblings do survive more often. Finally, associations between certain MHC alleles, or a large number of MHC alleles, and resistance to specific diseases have so far been found in a handful of species. Most of these associations involve humans or are experiments that have been done under controlled conditions. To me it is compelling that the selection pressure from pathogens on MHC genes can be visualised also under natural conditions in wild populations, as e.g. the great reed warblers." @default.
• W959897010 created "2016-06-24" @default.
• W959897010 creator A5068332089 @default.
• W959897010 date "2003-01-01" @default.
• W959897010 modified "2023-09-25" @default.
• W959897010 title "Avian MHC: variation and selection in the wild" @default.
• W959897010 hasPublicationYear "2003" @default.
• W959897010 type Work @default.
• W959897010 sameAs 959897010 @default.
• W959897010 citedByCount "7" @default.
• W959897010 crossrefType "dissertation" @default.
• W959897010 hasAuthorship W959897010A5068332089 @default.
• W959897010 hasConcept C104317684 @default.
• W959897010 hasConcept C137848329 @default.
• W959897010 hasConcept C144024400 @default.
• W959897010 hasConcept C149923435 @default.
• W959897010 hasConcept C170627219 @default.
• W959897010 hasConcept C207936829 @default.
• W959897010 hasConcept C2778814158 @default.
• W959897010 hasConcept C2779636034 @default.
• W959897010 hasConcept C2908647359 @default.
• W959897010 hasConcept C54355233 @default.
• W959897010 hasConcept C75268714 @default.
• W959897010 hasConcept C78458016 @default.
• W959897010 hasConcept C86803240 @default.
• W959897010 hasConceptScore W959897010C104317684 @default.
• W959897010 hasConceptScore W959897010C137848329 @default.
• W959897010 hasConceptScore W959897010C144024400 @default.
• W959897010 hasConceptScore W959897010C149923435 @default.
• W959897010 hasConceptScore W959897010C170627219 @default.
• W959897010 hasConceptScore W959897010C207936829 @default.
• W959897010 hasConceptScore W959897010C2778814158 @default.
• W959897010 hasConceptScore W959897010C2779636034 @default.
• W959897010 hasConceptScore W959897010C2908647359 @default.
• W959897010 hasConceptScore W959897010C54355233 @default.
• W959897010 hasConceptScore W959897010C75268714 @default.
• W959897010 hasConceptScore W959897010C78458016 @default.
• W959897010 hasConceptScore W959897010C86803240 @default.
• W959897010 hasLocation W9598970101 @default.
• W959897010 hasOpenAccess W959897010 @default.
• W959897010 hasPrimaryLocation W9598970101 @default.
• W959897010 hasRelatedWork W1019971215 @default.
• W959897010 hasRelatedWork W1508296236 @default.
• W959897010 hasRelatedWork W1544429659 @default.
• W959897010 hasRelatedWork W1871338315 @default.
• W959897010 hasRelatedWork W1971445847 @default.
• W959897010 hasRelatedWork W2021602487 @default.
• W959897010 hasRelatedWork W2052735134 @default.
• W959897010 hasRelatedWork W2084580594 @default.
• W959897010 hasRelatedWork W2085459606 @default.
• W959897010 hasRelatedWork W2122276216 @default.
• W959897010 hasRelatedWork W2157005749 @default.
• W959897010 hasRelatedWork W2568947170 @default.
• W959897010 hasRelatedWork W2605423593 @default.
• W959897010 hasRelatedWork W2609893932 @default.
• W959897010 hasRelatedWork W2679651626 @default.
• W959897010 hasRelatedWork W2855694621 @default.
• W959897010 hasRelatedWork W2895214256 @default.
• W959897010 hasRelatedWork W2924161587 @default.
• W959897010 hasRelatedWork W2948022964 @default.
• W959897010 hasRelatedWork W2986274640 @default.
• W959897010 isParatext "false" @default.
• W959897010 isRetracted "false" @default.
• W959897010 magId "959897010" @default.
• W959897010 workType "dissertation" @default.