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• W96000634 abstract "Objective To observe the impact of recombinant human endostatin (rhES) combined with hypoxia on the autophagy and apoptosis of human cervical cancer HeLa cells. Methods Under hypoxia, HeLa cells in logarithmic growth phase were treated with PBS, rhES, rhES combined with 3-methyladenine (3-MA, inhibitor of autophagy), respectively. Twenty-four hours later, cell apoptosis rate was detected using Hochest33528 staining and annexin V-FITC/PI staining and flow cytometry; the expressions of microtubule-associated protein light chain 3 (LC-3), Bcl-2, Bax proteins were determined using Western blotting. Results Hochest33528 staining suggested that cells of the hypoxia plus rhES group showed nuclear fragmentation; Annexin V-FITC/PI staining combined with flow cytometry revealed that the apoptosis rates were respectively (2.94±0.45)%, (21.38±0.92)% and (6.87±0.58)% in the three groups. It was significantly higher in the hypoxia plus rhES group than the other two groups. Western blotting showed that the expression levels of LC3 (LC-3II) and Bax increased and Bcl-2 decreased in the hypoxia plus rhES group as compared with the other two groups. Conclusion Endostatin combined hypoxia can induce autophagy and apoptosis of HeLa cells." @default.
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• W96000634 date "2014-12-01" @default.
• W96000634 modified "2023-10-17" @default.
• W96000634 title "Autophagy and apoptosis of HeLa cells induced by recombinant human endostatin combined with hypoxia" @default.
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