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• W960102570 abstract "M edical reversal occurs when an accepted practice—a diagnostic test, medication, or procedure—is overturned. The practice is not replaced by something better, but shown to be inferior to a preexisting, less intensive, or less invasive one. Sometimes the practice that is overturned is shown to be inferior to no intervention. Every physician is aware of emblematic cases of reversal, such as the use of hormone therapy in post-menopausal women. Medical reversal is common; well over 100 studies have been published in major medical journals over the last 10 years that provide strong evidence that an accepted medical practice was ineffective or harmful. The debates that follow these publications—whether the reversal concerns a screening test, surgical procedure, medical therapy, or systems intervention—are among the most contentious in medicine. These arguments are important ones; they ultimately decide howwe, as a profession, progress in our effort to provide highvalue care, and they articulate how we view the standards of evidence upon which we base our practice. The debates that follow reversals adhere to a predictable script, pitting minimalists against maximalists. These debates also place the practicing physician, who must decide what to actually recommend to patients, in a difficult position. Medical reversal occurs when practices are adopted before robust data is obtained. Even in our age of evidence-based medicine, this occurs frequently. A practice might be adopted because it makes excellent physiologic, biochemical, or molecular sense. It might be supported by observational trials. Interventions proven in severe or late-stage disease are sometimes used for less severe or preclinical disease, and data supporting care in young patients with few comorbidities may be extrapolated to elderly patients with coexisting diseases. Occasionally, well-done randomized trials find that a practice, adopted based on one of these less than robust forms of evidence, does not improve meaningful health outcomes. While there are examples where one of the above root causes predominates (for instance, interventional therapy for renal artery stenosis makes sound pathophysiologic sense, estrogen replacement was supported by robust observational trials, and SSRIs were proven effective in severe depression), most practices destined for reversal draw upon all of the weaker forms of evidence above. When a large, well-powered randomized trial suggests that a practice be abandoned, the debate begins. Deimplementation does not happen rapidly, and recent work suggests that the forces against abandonment are predictable. Commercial entities and specialty societies seem particularly unlikely to embrace data that casts doubt on accepted therapies. The ongoing debate about the value of mammography is typical of those that follow medical reversal. Evidence suggests that mammography reduces the risk of dying from breast cancer, but its effect on overall mortality is uncertain. If mammography does decrease overall mortality, the magnitude of this benefit is so small that it would require enormous studies to reveal it. Mammography is also associated with false-positive test results that cause real harm via anxiety and overdiagnosis. Those who argue that a recent negative mammography trial should put an end to the use of mammogram-based breast cancer screening contend that the randomized controlled trial is our best source of data. These Bminimalists^ cite the evidence of harm (overdiagnosis and overtreatment). They also note the lack of any robust data supporting mammography. They discount population data showing a small decrease in advanced breast cancer in the age of screening and argue that the promise of benefit associated with early detection is a false one without mortality data. On the other hand, “maximalists” contend that current breast cancer screening should continue despite the negative data. They argue that the studies we have are underpowered and use outdated imaging technology. Furthermore, they argue that abandoning screening for this potentially fatal disease is abrogating our responsibility to do the best for patients. These arguments are predictable and analogous to those made regarding reversed practices as diverse as PCI for stable coronary disease, arthroscopic knee surgery for degenerative meniscal tears, and prostate cancer screening. Each side’s argument contains truth and overstatement. Minimalists argue that, based on the newest research, the current practice is unwarranted. They argue that less can be more in health care and that our quest for high-value care necessitates abandoning interventions that cannot be clearly shown to benefit patients with regard to important clinical endpoints—mortality and quality of life. This group often completely discounts the less robust data that came before the most recent randomized trials. At their most extreme, they ignore the possibility that the Published online July 30, 2015" @default.
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• W960102570 date "2015-07-30" @default.
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• W960102570 title "Medical Debates and Medical Reversal" @default.
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