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- W96012743 abstract "Abstract Pyrimethamine, a substituted pyrimidine with potent folate antagonistic properties, was given orally to treat two episodes of meningeal leukemia in a longterm survivor with acute myeloblastic leukemia. Remissions of seven and at least 6 mo duration were obtained on the two occasions. Spinal fluid concentrations of pyrimethamine were 10-25% of the simultaneous plasma concentrations. Considerations regarding lipid solubility, body distribution, and easily reversible toxicity of pyrimethamine suggest that further therapeutic trials are warranted, especially in childhood lymphoblastic leukemia." @default.
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- W96012743 date "1971-08-01" @default.
- W96012743 modified "2023-10-17" @default.
- W96012743 title "Treatment of Meningeal Leukemia With Pyrimethamine" @default.
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- W96012743 doi "https://doi.org/10.1182/blood.v38.2.131.131" @default.
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