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- W960284382 abstract "The anthrax toxin receptors tumor endothelial marker-8 (TEM-8) and capillary morphogenesis gene-2 (CMG-2) are responsible for allowing entry of anthrax toxin into host cells. These receptors were first discovered due to their enhanced expression on endothelial cells undergoing blood vessel growth or angiogenesis in model systems. Inhibition of angiogenesis is an important strategy for current anti-cancer therapies and treatment of retinal diseases. Functional roles for TEM-8 and CMG-2 in angiogenesis have recently emerged. TEM-8 appears to regulate endothelial cell migration and tubule formation whereas a role for CMG-2 in endothelial proliferation has been documented. TEM-8 and CMG-2 bind differentially to extracellular matrix proteins including collagen I, collagen IV and laminin and these properties may be responsible for their apparent roles in regulating endothelial cell behavior during angiogenesis. TEM-8-binding moieties have also been suggested to be useful in selectively targeting anti-angiogenic and anti-tumorigenic therapies to tumor endothelium. Additionally, studies of modified forms of lethal toxin (LeTx) have demonstrated that targeted inhibition of MAPKs within tumor vessels may represent an efficacious anti-angiogenic strategy." @default.
- W960284382 created "2016-06-24" @default.
- W960284382 creator A5011470323 @default.
- W960284382 creator A5019113536 @default.
- W960284382 date "2011-01-01" @default.
- W960284382 modified "2023-10-16" @default.
- W960284382 title "Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapy" @default.
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- W960284382 doi "https://doi.org/10.2741/3806" @default.
- W960284382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3066103" @default.
- W960284382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21196249" @default.
- W960284382 hasPublicationYear "2011" @default.