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- W96037378 abstract "Research Article1 August 1991free access Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body. J.C. Izpisúa-Belmonte J.C. Izpisúa-Belmonte European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author H. Falkenstein H. Falkenstein European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author P. Dollé P. Dollé European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author A. Renucci A. Renucci European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author D. Duboule D. Duboule European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author J.C. Izpisúa-Belmonte J.C. Izpisúa-Belmonte European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author H. Falkenstein H. Falkenstein European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author P. Dollé P. Dollé European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author A. Renucci A. Renucci European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author D. Duboule D. Duboule European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author Author Information J.C. Izpisúa-Belmonte1, H. Falkenstein1, P. Dollé1, A. Renucci1 and D. Duboule1 1European Molecular Biology Laboratory, Heidelberg, Germany. The EMBO Journal (1991)10:2279-2289https://doi.org/10.1002/j.1460-2075.1991.tb07764.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The cloning, characterization and developmental expression patterns of two novel murine Hox genes, Hox-4.6 and Hox-4.7, are reported. Structural data allow us to classify the four Hox-4 genes located in the most upstream (5′) position in the HOX-4 complex as members of a large family of homeogenes related to the Drosophila homeotic gene Abdominal B (AbdB). It therefore appears that these vertebrate genes are derived from a selective amplification of an ancestral gene which gave rise, during evolution, to the most posterior of the insect homeotic genes so far described. In agreement with the structural colinearity, these genes have very posteriorly restricted expression profiles. In addition, their developmental expression is temporally regulated according to a cranio-caudal sequence which parallels the physical ordering of these genes along the chromosome. We discuss the phylogenetic alternative in the evolution of genetic complexity by amplifying either genes or regulatory sequences, as exemplified by this system in the mouse and Drosophila. Furthermore, the possible role of ‘temporal colinearity’ in the ontogeny of all coelomic (metamerized) metazoans showing a temporal anteroposterior morphogenetic progression is addressed. Previous ArticleNext Article Volume 10Issue 81 August 1991In this issue RelatedDetailsLoading ..." @default.
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- W96037378 title "Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body." @default.
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- W96037378 doi "https://doi.org/10.1002/j.1460-2075.1991.tb07764.x" @default.
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