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- W960498689 abstract "This chapter focuses primarily on the question of how the balance between immune protection and immune pathology is regulated. A fundamental biological dilemma is that the host has to deal with many different infectious pathogens and, even for a single species of parasite, with different strains. Eosinophils, typically associated with the Th2 response, are involved in immediate hypersensitivity reactions to the filarial worm Onchocerca volvulus. Humans with visceral leishmaniasis have high circulating levels of IL-10, which may partly explain their inability to control the infection. The clinical manifestations of weight loss, hypothermia, hypoglycemia, and increased levels of liver-derived enzymes in the blood, together with hepatic necrosis, suggested that the IL-10 knockout (KO) mice died in response to an overwhelming systemic immune response, resembling that observed during septic shock. Schistosomiasis is caused by one of three major species of helminth parasites, Schistosoma mansoni, S. haematobium, and S. japonicum. Malarial infection provokes high levels of tumor necrosis factor (TNF) and other proinflammatory cytokines as well as causing markedly elevated immunoglobulin production activation of complement and redistribution of lymphocytes from the peripheral circulation to the spleen and other organs. Although our knowledge of cytokines and other immunological mediators has grown enormously in the last 15 years, the current list is undoubtedly a small fraction of the total number of host molecules involved in the pathogenesis of parasitic disease." @default.
- W960498689 created "2016-06-24" @default.
- W960498689 creator A5075650859 @default.
- W960498689 creator A5086600642 @default.
- W960498689 date "2014-04-09" @default.
- W960498689 modified "2023-09-26" @default.
- W960498689 title "Pathology and Pathogenesis of Parasitic Disease" @default.
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- W960498689 doi "https://doi.org/10.1128/9781555817978.ch21" @default.
- W960498689 hasPublicationYear "2014" @default.