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• W96076257 abstract "Angiogenesis is an essential biologic event encountered in vertebrate animals (6,35,36,38,39,60,92). Embryonic development, the formation of inflammatory granulation tissue during wound healing, chronic inflammation, and the growth of malignant solid tumors represent physiologic and pathologic processes that are strictly dependent on neovascularization. The rate of normal capillary endothelial cell turnover in adults is typically measured in months or years (30,132). However, during wound repair and development of granulation tissue, resting endothelial cells become activated, leading to proteolytic degradation of their basement membrane and surrounding extracellular matrix, migration, proliferation, and establishment of newly functioning capillaries within a matter of days (60). An important feature of wound-associated angiogenesis is that it is locally controlled and transient. As rapidly as neovascularization occurs, these new vessels virtually disappear, returning the tissue vasculature to a homeostatic environment. This abrupt termination of angiogenesis in the context of the resolution of wound repair supports the notion of two possible mechanisms of control. First, there is probably a marked reduction in the synthesis and/or elaboration of angiogenic mediators. Second, a simultaneous increase occurs in the levels of factors that inhibit neovascularization (15). In contrast to the precise regulation of angiogenesis that accompanies wound repair, dysregulation of angiogenesis can lead to an imbalance in overexpression of angiogenic and underexpression of angiostatic factors that contributes to the pathogenesis of solid tumor growth. Thus, the complement of positive and negative regulators of angiogenesis may vary among different physiologic and pathologic settings. The recognition of this dual mechanism of control is critical in order to gain insight into this complex process and to understand its significance in regulating net angiogenesis." @default.
• W96076257 created "2016-06-24" @default.
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• W96076257 date "1999-01-01" @default.
• W96076257 modified "2023-09-27" @default.
• W96076257 title "C-X-C Chemokines and Lung Cancer Angiogenesis" @default.
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