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- W960802020 abstract "Patkany uterusban E2 kezeles hatasara az Akt foszforilacioja a Ser473 es a FOXO1 Ser 256 csoportokon fokozodik, amit ICI 182, 780 es Wortmannin gatol. Az Akt expresszio nem valtozott, a pAkt myomaban jelentősen fokozodott. A pAkt a proliferacios fazisban volt a legmagasabb. Myomakban a ciklus alatti Akt foszforilaciő fokozodasaval parhuzamosan az ER foszforilacioja, a cyclin D1 es Bcl-2 proteinek expresszioja is fokozodott. Myomaban az inaktiv pPTEN-Ser380 fokozodott a pAkt valtozasokkal megegyező modon. A myometriumokban pPTEN szintekben ciklus fazisoktol fuggő es pAkt-tol fuggetlen valtozasokat talaltunk. A PTEN inaktivacioja es Akt aktivacioja myomaban a menstruacios ciklus alatt parhuzamosan valtozott. A pFOXO1 (Ser256) protein szintje magasabb volt myomaban es valtozott a menstruacios ciklus alatt ill. menopauzaban. Myomaban a pFOXO-Ser256 elsősorban a magban volt kimutathato, feltehetően a nucleocytoplasmatikus transport zavara miatt, aminek az oka valoszinűleg a parhuzamosan meghatarozott 14-3-3 protein expresszio csokkenese.Myomaban a megvaltozott PTEN/ER/PI3K/Akt/FOXO1 jelatvitel a sejtekben sejttulelest biztosito (prosurvival) programok előterbe keruleset serkenti. Az ERalpha expresszio postmenopauzas endometriumban irregularisan valtozott. Az ER(Ser167) es Akt foszforilacioja magasabb ver E2 szintnel (>50pmol/L) fokozodott. A pAkt pozitivan korrelalt se E2 koncentracioval (r: 0.811, p 50pmol/L). The pAkt (Ser473) was abundant in endometrium of women with higher (>50 pmol/L) E2 concentration. The pAkt significantly correlated with Se E2 (r: 0.811, p<0.001) and pERalpha (r: 0.879, p< 0.001)." @default.
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- W960802020 title "Membran ösztrogén receptorok sejtszintű hatásainak vizsgálata human uterus hormonális szabályozásában és daganatos elváltozások patomechanizmusában = Cellular function of membrane estrogen receptors in hormonal control of human uterus and in pathomechanism of tumor formation" @default.
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