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- W960897391 abstract "The title compound (I) can be viewed as an enzyme affinity label produced by attachment of a relatively small leaving group (chlorine) to a hydrophilic substrate (inosine 5'-phosphate) in the expectation that the enzymic substrate binding sites will contain a preponderance of hydrophilic and hence potentially derivatizable amino acid residues. The chapter examines the indication that (I) forms covalent bonds at the nucleotide binding sites of two of four purine nucleotide utilizing enzymes. It explains the synthesis of (I) , reaction of (I) and inosine 5'-phosphate (IMP) dehydrogenase of aerobacter aerogenes, reaction of (I) and guanosine 5'-phosphate (GMP) reductase of aerobacter aerogenes, interaction of (I) with other mononucleotide-utilizing enzymes, and affinity labels related to (I)." @default.
- W960897391 created "2016-06-24" @default.
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- W960897391 date "1977-01-01" @default.
- W960897391 modified "2023-09-23" @default.
- W960897391 title "[28] 6-Chloropurine ribonucleoside 5′-phosphate" @default.
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- W960897391 doi "https://doi.org/10.1016/s0076-6879(77)46032-4" @default.
- W960897391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/198630" @default.
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