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• W9610411 abstract "The human beta-interferon promoter contains at least two positive acting domains (PRD I and PRD II). PRD I has been previously shown to stimulate basal transcription and to respond to induction by double-stranded RNA (dsRNA). Here we show that PRD II functions independently as a constitutive element that also responds to induction. A cellular factor that specifically binds to PRD II has been identified, and the levels of this factor increase markedly in extracts from cells treated with dsRNA. The inducible factor has a binding specificity that is indistinguishable from the transcription factor NF-kappa B. As has been shown for NF-kappa B, the PRD II-specific factor can be activated in uninduced extracts by treatment with detergent, suggesting that the inactive state is due to association with an inhibitory factor. Induction by dsRNA therefore provides a novel means for the post-translational activation of NF-kappa B. Potential binding sites for NF-kappa B are present in the 5' flanking regions of a number of genes involved in the immune response, several of which are inducible by dsRNA. These findings demonstrate a role for NF-kappa B in the physiological activation of genes in non-lymphoid cells." @default.
• W9610411 created "2016-06-24" @default.
• W9610411 creator A5029522995 @default.
• W9610411 creator A5052471070 @default.
• W9610411 date "1989-04-01" @default.
• W9610411 modified "2023-09-23" @default.
• W9610411 title "Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter." @default.
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• W9610411 doi "https://doi.org/10.1002/j.1460-2075.1989.tb03483.x" @default.
• W9610411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/400924" @default.
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• W9610411 hasPublicationYear "1989" @default.
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