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- W96129265 abstract "The occurrence of neurodegenerative disease substantially increases with age, which, in part, may be due to increased susceptibility to oxidative stress, inflammation and loss of autophagy (neuronal housekeeping). Polyphenols and ω-fatty acids, abundant in berries (e.g., blueberry, strawberry, or acai fruit) and walnuts, have been shown to protect brain cells in culture and animals against oxidative stress/inflammation, with enhanced memory and cognitive function in animals. We have investigated whether feeding rats with blueberry- or strawberry-supplemented diets, followed by irradiation with high energy and charge (HZE) particles, a model for accelerated aging, would elicit any protective effects in the brain. HZE irradiation disrupted key proteins in the hippocampus and striatum. Feeding animals with either berry diet, prior to irradiation, protected these brain regions against inflammation, oxidative stress and loss of autophagy. Moreover, autophagy activation was mediated by inhibiting the phosphorylation of mTOR and activating other proteins. Walnuts also elicited similar effects on the normal aging process when fed to aged animals. These molecular effects were further corroborated in vitro using BV2 microglia, HT22 neurons and E18 neuron-astrocyte cultures. This study extends molecular evidences for the health-promoting properties of berries and walnuts. Grant Funding Source: USDA intramural grant" @default.
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- W96129265 date "2012-04-01" @default.
- W96129265 modified "2023-10-17" @default.
- W96129265 title "Protective effects of berries and walnuts against the accelerated aging and age‐associated stress caused by irradiation in critical regions of rat brain" @default.
- W96129265 doi "https://doi.org/10.1096/fasebj.26.1_supplement.255.6" @default.
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